tshba thyroid stimulating hormone subunit beta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tshbaprovided by ZNC
Official Full Name: thyroid stimulating hormone subunit beta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030513-3
See related: Ensembl:ENSDARG00000033726 AllianceGenome:ZFIN:ZDB-GENE-030513-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tshb
Summary: Predicted to enable hormone activity. Acts upstream of or within development of secondary sexual characteristics and regulation of thyroid hormone generation. Predicted to be located in extracellular region. Is expressed in adenohypophyseal placode; head; hypophysis; and thyroid follicle. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (49081177..49085288)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (49082524..49086635)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models.
Title: Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within development of secondary sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyroid stimulating hormone subunit beta a

Names: thyroid stimulating hormone, beta subunit, a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.