U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pigu phosphatidylinositol glycan anchor biosynthesis, class U [ Rattus norvegicus (Norway rat) ]

Gene ID: 353304, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Symbol
Piguprovided by RGD
Full Name
phosphatidylinositol glycan anchor biosynthesis, class Uprovided by RGD
Primary source
RGD:727825
See related
EnsemblRapid:ENSRNOG00000025181 AllianceGenome:RGD:727825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
sakura; Cdc91l1; LRRGT00059
Summary
Predicted to contribute to GPI anchor binding activity. Predicted to be involved in GPI anchor biosynthetic process; attachment of GPI anchor to protein; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in plasma membrane. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 75.4), Lung (RPKM 61.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pigu in Genome Data Viewer
Location:
3q41
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164245011..164341444, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143784831..143881268, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150803096..150885597, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene 40S ribosomal protein S12-like Neighboring gene RNA, U6 small nuclear 524 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene microRNA 6334 Neighboring gene nuclear receptor coactivator 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer. Guo Z, et al. Nat Med, 2004 Apr. PMID 15034568
  2. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Hong Y, et al. Mol Biol Cell, 2003 May. PMID 12802054, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GPI anchor binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to GPI anchor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
part_of GPI-anchor transamidase complex ISO
Inferred from Sequence Orthology
more info
  
part_of GPI-anchor transamidase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol glycan anchor biosynthesis class U protein
Names
CDC91 cell division cycle 91-like 1
GPI transamidase component PIG-U
cell division cycle protein 91-like 1
liver regeneration-related protein LRRGT00059
protein CDC91-like 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181637.2 → NP_853668.1  phosphatidylinositol glycan anchor biosynthesis class U protein

    See identical proteins and their annotated locations for NP_853668.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8CHJ1
    UniProtKB/TrEMBL
    A6KI30, F1LPK9
    Related
    ENSRNOP00000032963.6, ENSRNOT00000034708.7
    Conserved Domains (1) summary
    pfam06728
    Location:20 → 394
    PIG-U; GPI transamidase subunit PIG-U

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164245011..164341444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105329.2 → XP_038961257.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAR3, F1LPK9
    Related
    ENSRNOP00000075495.2, ENSRNOT00000089935.3
    Conserved Domains (1) summary
    pfam06728
    Location:1 → 351
    PIG-U; GPI transamidase subunit PIG-U

  2. XM_039105330.2 → XP_038961258.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X2

    UniProtKB/TrEMBL
    A6KI31, F1LPK9
    Conserved Domains (1) summary
    pfam06728
    Location:1 → 310
    PIG-U; GPI transamidase subunit PIG-U

  3. XM_063284048.1 → XP_063140118.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X3

  4. XM_063284049.1 → XP_063140119.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHJ1.3 GenPept UniProtKB/Swiss-Prot:Q8CHJ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous