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Ns4 Nucleostemin 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35338, updated on 9-Dec-2024

Summary

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Official Symbol
Ns4provided by FlyBase
Official Full Name
Nucleostemin 4provided by FlyBase
Primary source
FLYBASE:FBgn0032882
Locus tag
Dmel_CG9320
See related
AllianceGenome:FB:FBgn0032882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38E.14; CG9320; Dmel\CG9320; dmNS4; ns4; NS4
Summary
Predicted to enable GTPase activity. Is expressed in organism. Orthologous to human GNL1 (G protein nucleolar 1 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ns4 in Genome Data Viewer
Location:
38E6-38E7; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20752476..20754655)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20752476..20754655)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transmembrane 9 superfamily protein member 2 Neighboring gene Female sterile (2) Ketel Neighboring gene Alpha-methylacyl-CoA racemase Neighboring gene RHAU helicase Neighboring gene diaphanous Neighboring gene caudal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
  2. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, et al. Genes Dev, 2008 Jul 15. PMID 18628395, Free PMC Article
  3. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
  4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleostemin 4
Names
CG9320-PA
Ns4-PA
nucleostemin ortholog 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20752476..20754655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136211.4 → NP_610055.1  nucleostemin 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIJ9
    Related
    FBpp0080939
    Conserved Domains (2) summary
    cd01857
    Location:163 → 390
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    TIGR03596
    Location:165 → 474
    GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIJ9 Q9VIJ9

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