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twit target of wit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35353, updated on 9-Dec-2024

Summary

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Official Symbol
twitprovided by FlyBase
Official Full Name
target of witprovided by FlyBase
Primary source
FLYBASE:FBgn0032895
Locus tag
Dmel_CG9335
See related
AllianceGenome:FB:FBgn0032895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD40063; CG9335; Dmel\CG9335
Summary
Involved in regulation of neurotransmitter secretion. Located in plasma membrane. Is expressed in several structures, including Bolwig organ; Bolwig organ primordium; embryonic central brain neurons; eye disc; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See twit in Genome Data Viewer
Location:
38F2-38F3; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20852578..20857113)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20852578..20857113)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44307 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene belly roll Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix. Nguyen TH, et al. Genetics, 2020 Sep. PMID 32737119, Free PMC Article
  2. Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element. Vuilleumier R, et al. Nucleic Acids Res, 2019 Jan 25. PMID 30476189, Free PMC Article
  3. Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family. Tanaka K, et al. Mol Biol Evol, 2015 Jul. PMID 25743545, Free PMC Article
  4. Role of BMP receptor traffic in synaptic growth defects in an ALS model. Deshpande M, et al. Mol Biol Cell, 2016 Oct 1. PMID 27535427, Free PMC Article
  5. The Ly6 neurotoxin-like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila. Kim NC, et al. Dev Neurobiol, 2012 Dec. PMID 22467519

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we characterize a gene that we have called twit, for target of wit, that encodes a Lymphocyte antigen 6 (Ly-6) toxin homolog.
    Title: The Ly6 neurotoxin-like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
target of wit
Names
CG9335-PA
twit-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20852578..20857113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136223.3 → NP_610067.1  target of wit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610067.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VII3
    Related
    FBpp0080955
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VII3 Q9VII3
Q9VII3.1

Gene LinkOut

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