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Itgbn Integrin betanu subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35368, updated on 9-Dec-2024

Summary

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Official Symbol
Itgbnprovided by FlyBase
Official Full Name
Integrin betanu subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0010395
Locus tag
Dmel_CG1762
See related
AllianceGenome:FB:FBgn0010395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
beta integrin; beta-Integrin; beta-nu; betagr;-nu; betaInt; betaInt nu; betaInt-&ngr; betaInt-nu; betaInt[nu]; betanu; betav; betaV-integrin; beta[nu]-integrin; beta[v]integrin; Beta[[nu]]; beta[[v]]; CG1762; CT5192; Dmel\CG1762; Fly betanu; intbetanu; integrin betaPs; Integrinbetanu; ITGbeta PSv; Itgbetanu; Itgbetav
Summary
Enables protein heterodimerization activity. Involved in several processes, including melanotic encapsulation of foreign target; muscle cell cellular homeostasis; and negative regulation of synaptic assembly at neuromuscular junction. Located in membrane. Part of integrin complex. Is expressed in several structures, including gastric caecum; gut section; and midgut imaginal island. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); ITGB8 (integrin subunit beta 8); and ITGBL1 (integrin subunit beta like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Itgbn in Genome Data Viewer
Location:
39A1-39A1; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21053033..21058044)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21053033..21058044)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44606 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene torn and diminished rhabdomeres

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster. Yee GH, et al. Development, 1993 Jul. PMID 8076521
  2. Protective effects of Phaseolus vulgaris lectin against viral infection in Drosophila. Ekowati H, et al. Drug Discov Ther, 2017. PMID 29332891
  3. Role for phagocytosis in the prevention of neoplastic transformation in Drosophila. Zhang M, et al. Genes Cells, 2020 Oct. PMID 32865275
  4. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. Lee JY, et al. J Neurosci, 2017 Mar 22. PMID 28219985, Free PMC Article
  5. Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells. Pert M, et al. Biol Open, 2015 Jan 23. PMID 25617422, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. integrin betanu serves as a phagocytosis receptor responsible for the clearance of apoptotic cells in Drosophila, independent of Draper
    Title: Integrin βν-mediated phagocytosis of apoptotic cells in Drosophila embryos.
  2. that integrin alphaPS3/betanu serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes.
    Title: Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila.
  3. Draper and integrin betanu cooperate in the phagocytic elimination of S. aureus by recognizing distinct cell wall components
    Title: Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila.
  4. Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required.
    Title: Multiple factors contribute to integrin-talin interactions in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 21057274-21057562 mobile_element_type = transposon:INE-1{}5354

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
Traceable Author Statement
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of integrin complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of integrin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrin betanu subunit
Names
CG1762-PA
CG1762-PB
Itgbn-PA
Itgbn-PB
beta-Integrin-nu
beta[[nu]]Integrin
beta[nu] integrin
beta[v]integrin
betanu integrin
betanuintegrin
betav integrin
integrin
integrin BetaPS
integrin beta neu
integrin beta v
integrin betanu
integrin bn
integrinbetanu

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21053033..21058044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078884.3 → NP_523608.2  integrin betanu subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523608.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UN88, Q27591, Q9VIG7
    UniProtKB/TrEMBL
    A0A0S0WGT1, F0JAH6
    Related
    FBpp0080990
    Conserved Domains (3) summary
    smart00187
    Location:38 → 460
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:524 → 552
    EGF_2; EGF-like domain
    pfam08725
    Location:748 → 785
    Integrin_b_cyt; Integrin beta cytoplasmic domain

  2. NM_001316404.1 → NP_001303333.1  integrin betanu subunit, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UN88, Q27591, Q9VIG7
    UniProtKB/TrEMBL
    A0A0S0WGT1, F0JAH6
    Conserved Domains (3) summary
    smart00187
    Location:38 → 460
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:524 → 552
    EGF_2; EGF-like domain
    pfam08725
    Location:748 → 785
    Integrin_b_cyt; Integrin beta cytoplasmic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WGT1 A0A0S0WGT1
Q27591.2 Q27591
Q3YNE6 Q3YNE6
Q3YNE7 Q3YNE7

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