U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

l(2)k14505 lethal (2) k14505 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35399, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
l(2)k14505provided by FlyBase
Official Full Name
lethal (2) k14505provided by FlyBase
Primary source
FLYBASE:FBgn0021856
Locus tag
Dmel_CG8674
See related
AllianceGenome:FB:FBgn0021856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8674; Dmel\CG8674
Summary
Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See l(2)k14505 in Genome Data Viewer
Location:
39C1-39C1; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21261168..21262411)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21261168..21262411)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein Neighboring gene mir-9374 stem loop Neighboring gene Hormone receptor-like in 39 Neighboring gene mir-4974 stem loop Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Wang ZA, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19966222, Free PMC Article
  2. Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. Levine SG, et al. Genome, 2007 Feb. PMID 17546078
  3. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
  4. Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy. Palozzi JM, et al. Cell Metab, 2022 Nov 1. PMID 36323236
  5. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton-transporting ATP synthase complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lethal (2) k14505
Names
CG8674-PA
CG8674-PB
l(2)k14505-PA
l(2)k14505-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21261168..21262411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273739.1 → NP_001260668.1  lethal (2) k14505, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3M6, Q9VID7
    Conserved Domains (1) summary
    pfam07542
    Location:39 → 159
    ATP12; ATP12 chaperone protein

  2. NM_136258.2 → NP_610102.1  lethal (2) k14505, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3M6, Q9VID7
    Related
    FBpp0081011
    Conserved Domains (1) summary
    pfam07542
    Location:39 → 159
    ATP12; ATP12 chaperone protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3M6 Q8T3M6
Q9VID7 Q9VID7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools