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nrv3 nervana 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35408, updated on 4-Jan-2025

Summary

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Official Symbol
nrv3provided by FlyBase
Official Full Name
nervana 3provided by FlyBase
Primary source
FLYBASE:FBgn0032946
Locus tag
Dmel_CG8663
See related
AllianceGenome:FB:FBgn0032946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8663; Dmel\CG8663; JYbeta1; nervana3; Nrv3
Summary
Predicted to enable ATPase activator activity. Involved in response to auditory stimulus and sensory perception of sound. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; embryonic central brain neurons; embryonic head sensory system; and ventral nerve cord. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nrv3 in Genome Data Viewer
Location:
39D2-39D2; 2-54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21380000..21393319)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21380000..21393319)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 39b Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological, anatomical, and behavioral changes after acoustic trauma in Drosophila melanogaster. Christie KW, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003166, Free PMC Article
  2. Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals. Dalla S, et al. Insect Biochem Mol Biol, 2013 Dec. PMID 24121093
  3. Substitutions in the cardenolide binding site and interaction of subunits affect kinetics besides cardenolide sensitivity of insect Na,K-ATPase. Dalla S, et al. Insect Biochem Mol Biol, 2017 Oct. PMID 28866054
  4. A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. Günesdogan U, et al. EMBO Rep, 2010 Oct. PMID 20814422, Free PMC Article
  5. Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration. Luan Z, et al. Exp Neurol, 2014 Nov. PMID 25205229, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nrv3 functions in Johnston's organ but not in scolopale cells, suggesting neuron specificity that parallels nrv2 scolopale cell-specific support of the catalytic ATPalpha.
    Title: Cell-type-specific roles of Na+/K+ ATPase subunits in Drosophila auditory mechanosensation.
  2. Nrv3 also encodes for a functional Na,K-ATPase beta-subunit.
    Title: Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eye.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 21383507-21383547 mobile_element_type = transposon:1360{}4176
  • Loc: 21383558-21384120 mobile_element_type = transposon:INE-1{}4141
  • Loc: 21384321-21384365 mobile_element_type = transposon:INE-1{}4142
  • Loc: 21385796-21385871 mobile_element_type = transposon:hopper{}4172
  • Loc: 21385964-21386569 mobile_element_type = transposon:hopper2{}4186

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nervana 3
Names
CG8663-PA
CG8663-PC
CG8663-PD
CG8663-PE
Na,K-ATPase beta-subunit
nrv3-PA
nrv3-PC
nrv3-PD
nrv3-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21380000..21393319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165378.1 → NP_724339.1  nervana 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JS69, Q86NM2
    Related
    FBpp0081047, FBtr0081519
    Conserved Domains (1) summary
    pfam00287
    Location:20 → 305
    Na_K-ATPase; Sodium / potassium ATPase beta chain

  2. NM_001273746.2 → NP_001260675.1  nervana 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260675.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDX8, Q86NM2
    Conserved Domains (1) summary
    pfam00287
    Location:20 → 307
    Na_K-ATPase; Sodium / potassium ATPase beta chain

  3. NM_165379.3 → NP_724340.1  nervana 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JS69, Q86NM2
    Related
    FBpp0081048
    Conserved Domains (1) summary
    pfam00287
    Location:20 → 305
    Na_K-ATPase; Sodium / potassium ATPase beta chain

  4. NM_136264.6 → NP_610108.1  nervana 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JS69, Q86NM2
    Related
    FBpp0081046
    Conserved Domains (1) summary
    pfam00287
    Location:20 → 305
    Na_K-ATPase; Sodium / potassium ATPase beta chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDX8 M9PDX8
Q7JS69 Q7JS69
Q86NM2 Q86NM2

Gene LinkOut

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