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nolo no long nerve cord [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35424, updated on 4-Jan-2025

Summary

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Official Symbol
noloprovided by FlyBase
Official Full Name
no long nerve cordprovided by FlyBase
Primary source
FLYBASE:FBgn0051619
Locus tag
Dmel_CG31619
See related
AllianceGenome:FB:FBgn0051619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13236; CG2122; CG2131; CG31619; CT6940; Dmel\CG31619
Summary
Involved in ventral cord development. Is expressed in several structures, including Bolwig organ primordium; CNS glial cell; VL fascicle; ganglia; and gut section. Orthologous to human ADAMTSL1 (ADAMTS like 1) and ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See nolo in Genome Data Viewer
Location:
39F1-39F3; 2-54 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21684106..21729051)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21684106..21729051)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46066 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 254 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene steppke Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression. Frantz SI, et al. G3 (Bethesda), 2023 May 2. PMID 36857313, Free PMC Article
  2. Secreted ADAMTS-like proteins as regulators of connective tissue function. Taye N, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38284126
  3. Chromosome-level organization of the regulatory genome in the Drosophila nervous system. Mohana G, et al. Cell, 2023 Aug 31. PMID 37536338, Free PMC Article
  4. Glia ECM interactions are required to shape the Drosophila nervous system. Meyer S, et al. Mech Dev, 2014 Aug. PMID 24859129
  5. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease. Hsieh YC, et al. Cell Rep, 2019 Oct 8. PMID 31597093, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 21686534-21687088 mobile_element_type = transposon:mariner2{}513
  • Loc: 21689319-21689848 mobile_element_type = transposon:INE-1{}4894
  • Loc: 21698710-21699142 mobile_element_type = transposon:INE-1{}4907
  • Loc: 21699148-21699326 mobile_element_type = transposon:INE-1{}4908
  • Loc: 21703829-21704026 mobile_element_type = transposon:INE-1{}4909
  • Loc: 21705310-21706714 mobile_element_type = transposon:HB{}515
  • Loc: 21706718-21707775 mobile_element_type = transposon:FB{}nolo[FB]
  • Loc: 21707900-21708819 mobile_element_type = transposon:INE-1{}2259
  • Loc: 21708836-21708973 mobile_element_type = transposon:INE-1{}2261
  • Loc: 21710833-21710967 mobile_element_type = transposon:INE-1{}4912
  • Loc: 21711632-21711828 mobile_element_type = transposon:INE-1{}4913
  • Loc: 21715211-21715289 mobile_element_type = transposon:gypsy12{}5498
  • Loc: 21715789-21716113 mobile_element_type = transposon:INE-1{}4915
  • Loc: 21717919-21717969 mobile_element_type = transposon:INE-1{}4923
  • Loc: 21727643-21727769 mobile_element_type = transposon:INE-1{}4926

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
no long nerve cord
Names
CG31619-PA
CG31619-PB
CG31619-PC
CG31619-PD
CG31619-PE
CG31619-PF
CG31619-PG
nolo-PA
nolo-PB
nolo-PC
nolo-PD
nolo-PE
nolo-PF
nolo-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21684106..21729051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259199.2 → NP_001246128.1  no long nerve cord, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8N3
    Conserved Domains (3) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1355 → 1384
    PLAC; PLAC (protease and lacunin) domain

  2. NM_001299197.1 → NP_001286126.1  no long nerve cord, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PTX3, X2JEX4
    Conserved Domains (2) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats

  3. NM_165396.3 → NP_724359.1  no long nerve cord, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9Q7
    Related
    FBpp0085256
    Conserved Domains (3) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1314 → 1343
    PLAC; PLAC (protease and lacunin) domain

  4. NM_001042909.3 → NP_001036374.1  no long nerve cord, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8N3
    Conserved Domains (3) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1355 → 1384
    PLAC; PLAC (protease and lacunin) domain

  5. NM_001169569.3 → NP_001163040.1  no long nerve cord, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163040.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHP3
    Conserved Domains (3) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1349 → 1378
    PLAC; PLAC (protease and lacunin) domain

  6. NM_001299198.1 → NP_001286127.1  no long nerve cord, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAM1
    Conserved Domains (3) summary
    smart00408
    Location:838 → 895
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1307 → 1336
    PLAC; PLAC (protease and lacunin) domain

  7. NM_165397.3 → NP_724360.1  no long nerve cord, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PTX3, Q95R33, Q9V9Q9
    Related
    FBpp0085257
    Conserved Domains (2) summary
    smart00408
    Location:845 → 902
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:78 → 124
    TSP1; Thrombospondin type 1 repeats
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHP3 E1JHP3
Q0E8N3 Q0E8N3
Q8MRW9 Q8MRW9
Q9V9Q7 Q9V9Q7
Q9V9Q9 Q9V9Q9
X2JAM1 X2JAM1
X2JEX4 X2JEX4

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