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CG6675 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35439, updated on 9-Dec-2024

Summary

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Official Symbol
CG6675provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032973
Locus tag
Dmel_CG6675
See related
AllianceGenome:FB:FBgn0032973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6675
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6675 in Genome Data Viewer
Location:
40E3-40E3; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22108964..22110449)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22108964..22110449)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46480 Neighboring gene uncharacterized protein Neighboring gene Cyclin K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome features of innate immune memory in Drosophila. Fuse N, et al. PLoS Genet, 2022 Oct. PMID 36252180, Free PMC Article
  2. Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster. Zhikrevetskaya S, et al. PLoS One, 2015. PMID 26248317, Free PMC Article
  3. The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology. Rounds JC, et al. Genetics, 2022 Jan 4. PMID 34791182, Free PMC Article
  4. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
  5. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6675-PB
CG6675-PC
NP_001286130.1
NP_610132.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22108964..22110449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136288.2 → NP_610132.3  uncharacterized protein Dmel_CG6675, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610132.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9A0N1, Q6IDD7, Q9V9P0
    Conserved Domains (1) summary
    cd00707
    Location:116 → 381
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  2. NM_001299201.1 → NP_001286130.1  uncharacterized protein Dmel_CG6675, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286130.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9A0N1, X2J9D7
    Conserved Domains (1) summary
    cd00707
    Location:112 → 377
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9P0 Q9V9P0
X2J9D7 X2J9D7

Gene LinkOut

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