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Atf6 Atf6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35480, updated on 4-Jan-2025

Summary

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Official Symbol
Atf6provided by FlyBase
Official Full Name
Atf6provided by FlyBase
Primary source
FLYBASE:FBgn0033010
Locus tag
Dmel_CG3136
See related
AllianceGenome:FB:FBgn0033010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atf6; ATF6; CG3136; DM15; Dmel\CG3136
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to several human genes including ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Atf6 in Genome Data Viewer
Location:
41D4-41E1; 2-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5144733..5154756)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1032238..1042261)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43256 Neighboring gene gustavus Neighboring gene Nipped-A Neighboring gene long non-coding RNA:CR41443

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ER Stress Activates the TOR Pathway through Atf6. Allen D, et al. J Mol Signal, 2018 Apr 23. PMID 30210580, Free PMC Article
  2. ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk-Signaling Beyond (ER) Stress Response. Kumar V, et al. Biomolecules, 2021 Jan 28. PMID 33525374, Free PMC Article
  3. Unfolded protein response in Drosophila: why another model can make it fly. Ryoo HD, et al. Cell Cycle, 2007 Apr 1. PMID 17387279
  4. Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer's Disease. Zarini-Gakiye E, et al. CNS Neurol Disord Drug Targets, 2021. PMID 33573583
  5. Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, et al. Front Physiol, 2023. PMID 37324401, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 5148076-5148127 mobile_element_type = transposon:INE-1{}2435
  • Loc: 5150040-5150239 mobile_element_type = transposon:INE-1{}2436
  • Loc: 5151525-5151586 mobile_element_type = transposon:INE-1{}2437
  • Loc: 5151980-5152474 mobile_element_type = transposon:Cr1a{}2561
  • Loc: 5154148-5154543 mobile_element_type = transposon:INE-1{}2439

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Atf6
Names
Atf6-PA
Atf6-PB
Atf6-PC
CG3136-PA
CG3136-PB
CG3136-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5144733..5154756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165423.2 → NP_724403.1  Atf6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2V1
    Related
    FBpp0085415
    Conserved Domains (1) summary
    cd14700
    Location:285 → 336
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

  2. NM_206023.2 → NP_995745.1  Atf6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX87
    Conserved Domains (1) summary
    cd14700
    Location:287 → 338
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

  3. NM_136315.3 → NP_610159.1  Atf6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2V1
    Related
    FBpp0085416
    Conserved Domains (1) summary
    cd14700
    Location:285 → 336
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K2V1 Q7K2V1
Q8SX87 Q8SX87

Gene LinkOut

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