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d4 d4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35485, updated on 4-Jan-2025

Summary

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Official Symbol
d4provided by FlyBase
Official Full Name
d4provided by FlyBase
Primary source
FLYBASE:FBgn0033015
Locus tag
Dmel_CG2682
See related
AllianceGenome:FB:FBgn0033015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2682; D4; dd4; Dd4; Dmel\CG2682
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in nervous system development. Part of brahma complex. Is expressed in organism. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to several human genes including DPF2 (double PHD fingers 2) and DPF3 (double PHD fingers 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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Location:
41E3-41E4; 2-55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5259004..5295965)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1146509..1183470)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nipped-A Neighboring gene long non-coding RNA:CR41443 Neighboring gene super sex combs Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster. Nabirochkina E, et al. Mech Dev, 2002 Jun. PMID 12175496
  2. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Mashtalir N, et al. Cell, 2018 Nov 15. PMID 30343899, Free PMC Article
  3. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article
  4. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
  5. In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin. Tilly BC, et al. Elife, 2021 Jul 27. PMID 34313222, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 5259068-5259406 mobile_element_type = transposon:INE-1{}2485
  • Loc: 5260896-5261101 mobile_element_type = transposon:Tc1-2{}2579
  • Loc: 5262940-5264917 mobile_element_type = transposon:gypsy12{}3705
  • Loc: 5264978-5265068 mobile_element_type = transposon:1360{}3604
  • Loc: 5265687-5265985 mobile_element_type = transposon:INE-1{}3127
  • Loc: 5275704-5275779 mobile_element_type = transposon:INE-1{}3140
  • Loc: 5277195-5282574 mobile_element_type = transposon:G4{}2931
  • Loc: 5277520-5282296 mobile_element_type = transposon:G5{}3657
  • Loc: 5283685-5284144 mobile_element_type = transposon:Cr1a{}638
  • Loc: 5291385-5291442 mobile_element_type = transposon:G4{}3590
  • Loc: 5291457-5291743 mobile_element_type = transposon:INE-1{}3142

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of brahma complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
d4
Names
CG2682-PA
CG2682-PB
CG2682-PC
CG2682-PD
d4-PA
d4-PB
d4-PC
d4-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5259004..5295965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165425.3 → NP_724405.2  d4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724405.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9P4
    Conserved Domains (2) summary
    cd15530
    Location:286 → 331
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15619
    Location:229 → 284
    PHD1_d4; PHD finger 1 found in d4 gene family proteins

  2. NM_136319.4 → NP_610163.1  d4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3G5
    Related
    FBpp0085418
    Conserved Domains (3) summary
    cd15530
    Location:444 → 489
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15619
    Location:387 → 442
    PHD1_d4; PHD finger 1 found in d4 gene family proteins
    pfam14051
    Location:30 → 98
    Requiem_N; N-terminal domain of DPF2/REQ

  3. NM_001273778.1 → NP_001260707.1  d4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260707.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEC3
    Conserved Domains (3) summary
    cd15530
    Location:443 → 488
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15619
    Location:386 → 441
    PHD1_d4; PHD finger 1 found in d4 gene family proteins
    pfam14051
    Location:30 → 98
    Requiem_N; N-terminal domain of DPF2/REQ

  4. NM_165424.3 → NP_724404.1  d4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724404.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6E6
    Related
    FBpp0085419
    Conserved Domains (3) summary
    cd15530
    Location:442 → 487
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15619
    Location:385 → 440
    PHD1_d4; PHD finger 1 found in d4 gene family proteins
    pfam14051
    Location:30 → 98
    Requiem_N; N-terminal domain of DPF2/REQ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEC3 A0A0B4KEC3
A1Z6E6 A1Z6E6
Q0E9P4 Q0E9P4
Q7K3G5 Q7K3G5

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