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COX4L Cytochrome c oxidase subunit 4-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35491, updated on 9-Dec-2024

Summary

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Official Symbol
COX4Lprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 4-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0033020
Locus tag
Dmel_CG10396
See related
AllianceGenome:FB:FBgn0033020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT07685; CG10396; COX IV; cox4; COXIV; CX41; CX42; Dmel\CG10396; IV
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See COX4L in Genome Data Viewer
Location:
41E5-41E5; 2-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5353994..5354723)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1241499..1242228)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 20 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42646

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. COX4-like, a Nuclear-Encoded Mitochondrial Gene Duplicate, Is Essential for Male Fertility in Drosophila melanogaster. Eslamieh M, et al. Genes (Basel), 2022 Feb 25. PMID 35327978, Free PMC Article
  2. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
  3. State of Drosophila melanogaster Ovaries after a Full Cycle of Gametogenesis under Microgravity Modeling: Cellular Respiration and the Content of Cytoskeletal Proteins. Usik MA, et al. Int J Mol Sci, 2021 Aug 26. PMID 34502148, Free PMC Article
  4. Mitochondrial Respiration in Drosophila Ovaries after a Full Cycle of Oogenesis under Simulated Microgravity. Ogneva IV, et al. Curr Issues Mol Biol, 2021 May 22. PMID 34067415, Free PMC Article
  5. Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. Ogneva IV, et al. Int J Mol Sci, 2020 Aug 20. PMID 32825268, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 4-like
Names
CG10396-PA
CG10396-PB
COX4L-PA
COX4L-PB
c oxidase
cytochrome
cytochrome c oxidase
cytochrome c oxidase subunit IV

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5353994..5354723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273779.1 → NP_001260708.1  cytochrome c oxidase subunit 4-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEI0
    Conserved Domains (1) summary
    pfam02936
    Location:31 → 162
    COX4; Cytochrome c oxidase subunit IV

  2. NM_136324.4 → NP_610168.1  cytochrome c oxidase subunit 4-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610168.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T4H8, Q9V9F6
    Related
    FBpp0085425
    Conserved Domains (1) summary
    pfam02936
    Location:45 → 176
    COX4; Cytochrome c oxidase subunit IV
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEI0 A0A0B4KEI0
Q8T4H8 Q8T4H8

Gene LinkOut

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