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TpnC4 Troponin C isoform 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35498, updated on 4-Jan-2025

Summary

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Official Symbol
TpnC4provided by FlyBase
Official Full Name
Troponin C isoform 4provided by FlyBase
Primary source
FLYBASE:FBgn0033027
Locus tag
Dmel_CG12408
See related
AllianceGenome:FB:FBgn0033027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH03361; CG12408; Dmel\CG12408; DmTnC4; DmTpnC41F; DmTpnCIIIb; TnC; tnC4; Tnc4; TnC4; TNC41F6; TpnC IIIb; tpnc4; TPnC4; TpnC41F; TpnCIIIb
Summary
Predicted to enable calcium ion binding activity. Involved in flight. Predicted to be active in centrosome and cytoplasm. Is expressed in adult head; indirect flight muscle cell; and organism. Orthologous to human CALML6 (calmodulin like 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See TpnC4 in Genome Data Viewer
Location:
41F2-41F3; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5503437..5507866, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1390942..1395371, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene straw Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene uncharacterized protein Neighboring gene Fission, mitochondrial 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle. Eldred CC, et al. J Muscle Res Cell Motil, 2014 Aug. PMID 25134799, Free PMC Article
  2. Neural control and precision of flight muscle activation in Drosophila. Lehmann FO, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2017 Jan. PMID 27942807, Free PMC Article
  3. Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. Chechenova MB, et al. Mol Biol Cell, 2017 Mar 15. PMID 28077621, Free PMC Article
  4. Roles of the troponin isoforms during indirect flight muscle development in Drosophila. Singh SH, et al. J Genet, 2014 Aug. PMID 25189233
  5. Expression patterns of the whole troponin C gene repertoire during Drosophila development. Herranz R, et al. Gene Expr Patterns, 2004 Mar. PMID 15161098

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5504119-5503736 mobile_element_type = transposon:INE-1{}4260
  • Loc: c5504555-5504509 mobile_element_type = transposon:INE-1{}4263
  • Loc: c5507237-5507100 mobile_element_type = transposon:INE-1{}4264

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in flight IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
troponin C isoform 4
Names
CG12408-PA
CG12408-PB
TpnC4-PA
TpnC4-PB
troponin C
troponin C 41F
troponin C4
troponin-C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5503437..5507866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169584.2 → NP_001163055.1  troponin C isoform 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K860, Q8SZM6
    Conserved Domains (2) summary
    PTZ00184
    Location:1 → 152
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:90 → 152
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_136329.3 → NP_610173.2  troponin C isoform 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610173.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K860, Q8SZM6
    Related
    FBpp0085411
    Conserved Domains (2) summary
    PTZ00184
    Location:1 → 152
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:90 → 152
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K860 Q7K860
Q8SZM6 Q8SZM6

Gene LinkOut

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