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kune kune-kune [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35504, updated on 9-Dec-2024

Summary

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Official Symbol
kuneprovided by FlyBase
Official Full Name
kune-kuneprovided by FlyBase
Primary source
FLYBASE:FBgn0033032
Locus tag
Dmel_CG1298
See related
AllianceGenome:FB:FBgn0033032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1298; Dmel\CG1298; Kune
Summary
Involved in establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; and septate junction assembly. Located in membrane and pleated septate junction. Is expressed in several structures, including adult head; clypeo-labral primordium; epidermis; gland; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See kune in Genome Data Viewer
Location:
41F6-41F6; 2-55 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5671741..5672800)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1559246..1560305)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45472 Neighboring gene uncharacterized protein Neighboring gene scarface Neighboring gene Cytosolic non-specific dipeptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. QuBiT: a quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in the Drosophila trachea. Yang R, et al. Development, 2019 May 16. PMID 30967427, Free PMC Article
  2. Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut. MacMillan HA, et al. Sci Rep, 2017 Aug 18. PMID 28821771, Free PMC Article
  3. Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. Yanagihashi Y, et al. J Cell Sci, 2012 Apr 15. PMID 22328496
  4. A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut. Izumi Y, et al. J Cell Sci, 2012 Oct 15. PMID 22854041
  5. Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay. DaCrema D, et al. Development, 2021 Mar 19. PMID 33658221, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
    Title: Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
NOT involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in pleated septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in septate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septate junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in septate junction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
kune-kune
Names
CG1298-PA
kune-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5671741..5672800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136335.3 → NP_610179.2  kune-kune [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610179.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6H0, Q8SY89
    Related
    FBpp0085373
    Conserved Domains (1) summary
    pfam13903
    Location:16 → 190
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6H0 A1Z6H0
Q8SY89 Q8SY89

Gene LinkOut

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