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SmydA-5 SET and MYND domain containing, arthropod-specific, member 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35538, updated on 4-Jan-2025

Summary

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Official Symbol
SmydA-5provided by FlyBase
Official Full Name
SET and MYND domain containing, arthropod-specific, member 5provided by FlyBase
Primary source
FLYBASE:FBgn0033061
Locus tag
Dmel_CG14590
See related
AllianceGenome:FB:FBgn0033061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14590; Dmel\CG14590
Summary
Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SmydA-5 in Genome Data Viewer
Location:
42A9-42A9; 2-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6078641..6080572, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1966146..1968077, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lethal (2) k09848 Neighboring gene uncharacterized protein Neighboring gene Arsenic resistance protein 2 Neighboring gene Ecdysone receptor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
  2. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
  3. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
  4. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
  5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-lysine N-methyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET and MYND domain containing, arthropod-specific, member 5
Names
CG14590-PA
SmydA-5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6078641..6080572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136358.3 → NP_610202.3  SET and MYND domain containing, arthropod-specific, member 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610202.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3Z4, Q9V9K6
    Related
    FBpp0085358
    Conserved Domains (2) summary
    pfam00856
    Location:185 → 295
    SET; SET domain
    pfam01753
    Location:7 → 43
    zf-MYND; MYND finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3Z4 Q8T3Z4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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