EcR Ecdysone receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: EcRprovided by FlyBase
Official Full Name: Ecdysone receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0000546
Locus tag: Dmel_CG1765
See related: AllianceGenome:FB:FBgn0000546
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0229075.1; CG1765; CG8347; dECR; DEcR; Dhr23; dmEcR; DmEcR; Dmel\CG1765; EcdR; ecr; Ecr; ECR; EcR-A; EcR-B; EcR-B1; ECR-C; Ecr1B; EcR1b; EcRA; EcRB; EcRB-1; EcrB1; EcRB1; EcRC; lie; ms(2)06410; ms(2)42A; NR1H1; snt; Usp; USP
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; and transcription coregulator binding activity. Involved in several processes, including heart development; instar larval or pupal development; and nervous system development. Acts upstream of with a positive effect on regulation of macroautophagy. Located in several cellular components, including dendrite; nucleus; and polytene chromosome. Part of activator ecdysone receptor complex and repressor ecdysone receptor complex. Is expressed in several structures, including epithelium; follicle cell; gland; gut section; and larval imaginal tissue. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 42A9-42A12; 2-55 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6087873..6169087, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1975378..2056592, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fecundity is optimized by levels of nutrient signal-dependent expression of Dve and EcR in Drosophila male accessory gland.
Title: Fecundity is optimized by levels of nutrient signal-dependent expression of Dve and EcR in Drosophila male accessory gland.
The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level.
Title: The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level.
Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.
Title: Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.
Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
Title: Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
Proximity-dependent biotin labelling reveals CP190 as an EcR/Usp molecular partner.
Title: Proximity-dependent biotin labelling reveals CP190 as an EcR/Usp molecular partner.
Mating induces switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila secondary cells.
Title: Mating induces switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila secondary cells.
study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor
Title: EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes.
The BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of gamma and alpha'beta' MB neurons
Title: Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.
Results shows that ectopic overexpression of mir34 downregulates EcR in mushroom body (MB) neurons suggesting that EcR expression may be under the regulation of mir34 in drosophila.
Title: Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor.
The ecdysone receptor (EcR), which is responsible for initiating the larval-to-adult transition, colocalized with 14-3-3epsilon in wild-type fat body tissues.
Title: Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2259 (e-PCR)
- UniSTS:43442

ha2348 (e-PCR)
- UniSTS:515532

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c6159410-6159321 mobile_element_type = transposon:INE-1{}6230
Loc: c6160802-6160638 mobile_element_type = transposon:INE-1{}6232
Loc: c6164596-6163223 mobile_element_type = transposon:Tc1-2{}1730
Loc: c6164830-6164800 mobile_element_type = transposon:1360{}1727
Loc: c6166506-6166405 mobile_element_type = transposon:INE-1{}6239

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ecdysone binding	IDA Inferred from Direct Assay more info	PubMed
enables ecdysone binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to nuclear receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid binding	NAS Non-traceable Author Statement more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based embryonic cuticle biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal vessel heart proper cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ecdysone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ecdysone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval central nervous system remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval central nervous system remodeling	TAS Traceable Author Statement more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval wandering behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of Malpighian tubule diameter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of development, heterochronic	TAS Traceable Author Statement more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activator ecdysone receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ecdysone receptor holocomplex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ecdysone receptor holocomplex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	NAS Non-traceable Author Statement more info	PubMed
part_of repressor ecdysone receptor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: ecdysone receptor

Names: CG1765-PA; CG1765-PB; CG1765-PC; CG1765-PD; CG1765-PE; CG1765-PG; EcR-PA; EcR-PB; EcR-PC; EcR-PD; EcR-PE; EcR-PG; Ecdysone-R; ecdyson receptor 1b; ecdysone receptor complex; ecdysone-Receptor; ecdysteroid receptor; ecdysterone receptor; long island expressway; male sterile(2)42A; snaggletooth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6087873..6169087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169590.2 → NP_001163061.1 ecdysone receptor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163061.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34021, Q0E9N8, Q6AWL4, Q8SY10, Q95TS4, Q9V9K8

UniProtKB/TrEMBL

E1JGY2

Conserved Domains (2) summary

cd06938
Location:420 → 652

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:261 → 351

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
NM_165461.3 → NP_724456.1 ecdysone receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724456.1

Status: REVIEWED

UniProtKB/TrEMBL

A4UZ51

Related

FBpp0085349

Conserved Domains (2) summary

cd06938
Location:391 → 623

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:232 → 322

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
NM_165463.2 → NP_724458.1 ecdysone receptor, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724458.1

Status: REVIEWED

UniProtKB/TrEMBL

A4UZ51

Related

FBpp0085351

Conserved Domains (2) summary

cd06938
Location:391 → 623

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:232 → 322

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
NM_165464.3 → NP_724459.1 ecdysone receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724459.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34021

Related

FBpp0085353

Conserved Domains (2) summary

cd06938
Location:211 → 443

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:52 → 142

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
NM_165462.2 → NP_724457.1 ecdysone receptor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724457.1

Status: REVIEWED

UniProtKB/TrEMBL

A4UZ51

Related

FBpp0085350

Conserved Domains (2) summary

cd06938
Location:391 → 623

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:232 → 322

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
NM_165465.3 → NP_724460.1 ecdysone receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724460.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34021, Q0E9N8, Q6AWL4, Q8SY10, Q95TS4, Q9V9K8

UniProtKB/TrEMBL

E1JGY2

Related

FBpp0085352

Conserved Domains (2) summary

cd06938
Location:420 → 652

NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family

cd07161
Location:261 → 351

NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers