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bin3 bicoid-interacting protein 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35552, updated on 9-Dec-2024

Summary

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Official Symbol
bin3provided by FlyBase
Official Full Name
bicoid-interacting protein 3provided by FlyBase
Primary source
FLYBASE:FBgn0263144
Locus tag
Dmel_CG8276
See related
AllianceGenome:FB:FBgn0263144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bin3; CG8276; Dmel\CG8276; l(2)SH1014; l(2)SH2 1014
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and snRNA binding activity. Involved in developmental process and negative regulation of translation. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; amnioserosa; ganglia; mesoderm; and nephrocyte. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See bin3 in Genome Data Viewer
Location:
42A13-42A14; 2-55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6214568..6240602)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2102073..2128107)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene uncharacterized protein Neighboring gene tomboy40 Neighboring gene Tetratricopeptide repeat domain 7 Neighboring gene Phospholipase D Neighboring gene long non-coding RNA:CR46075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs. Peng Q, et al. Sci Adv, 2023 Dec 15. PMID 38100593, Free PMC Article
  2. Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. Zhu W, et al. Gene, 2000 Mar 21. PMID 10717484
  3. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
  4. Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster. Palumbo RJ, et al. Genetics, 2024 Jan 3. PMID 37982586, Free PMC Article
  5. Distinguishing direct from indirect roles for bicoid mRNA localization factors. Weil TT, et al. Development, 2010 Jan. PMID 20023172, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster.
    Title: Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster.
  2. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs.
    Title: Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs.
  3. Bicoid recruits Bin3 to the caudal 3' UTR.
    Title: The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.
  4. Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
    Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 6234498-6234554 mobile_element_type = transposon:INE-1{}1746

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bicoid-interacting protein 3
Names
Bicoid-interacting protein 3
CG8276-PA
CG8276-PB
CG8276-PC
CG8276-PD
bicoid interacting protein 3
bin3-PA
bin3-PB
bin3-PC
bin3-PD
lethal (2) SH1014
NP_001260724.1
NP_001303336.1
NP_523626.2
NP_724468.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6214568..6240602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078902.3 → NP_523626.2  bicoid-interacting protein 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523626.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K480, Q86LF5, Q9NJV6
    UniProtKB/TrEMBL
    E2QC61
    Related
    FBpp0085336
    Conserved Domains (2) summary
    pfam06859
    Location:1004 → 1112
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:820 → 867
    Methyltransf_18; Methyltransferase domain

  2. NM_001316407.1 → NP_001303336.1  bicoid-interacting protein 3, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K480, Q86LF5, Q9NJV6
    UniProtKB/TrEMBL
    E2QC61
    Conserved Domains (2) summary
    pfam06859
    Location:1004 → 1112
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:820 → 867
    Methyltransf_18; Methyltransferase domain

  3. NM_165468.2 → NP_724468.1  bicoid-interacting protein 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K480, Q86LF5, Q9NJV6
    UniProtKB/TrEMBL
    E2QC61
    Related
    FBpp0085337
    Conserved Domains (2) summary
    pfam06859
    Location:1004 → 1112
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:820 → 867
    Methyltransf_18; Methyltransferase domain

  4. NM_001273795.1 → NP_001260724.1  bicoid-interacting protein 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K480, Q86LF5, Q9NJV6
    UniProtKB/TrEMBL
    E2QC61
    Conserved Domains (2) summary
    pfam06859
    Location:1004 → 1112
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:820 → 867
    Methyltransf_18; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QC61 E2QC61
Q7K480.1 Q7K480

Gene LinkOut

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