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tomboy40 tomboy40 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35553, updated on 9-Dec-2024

Summary

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Official Symbol
tomboy40provided by FlyBase
Official Full Name
tomboy40provided by FlyBase
Primary source
FLYBASE:FBgn0033074
Locus tag
Dmel_CG8330
See related
AllianceGenome:FB:FBgn0033074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8330; Dmel\CG8330; Tomboy40
Summary
Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. Is expressed in adult head; germline cell; and testis. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40) and TOMM40L (translocase of outer mitochondrial membrane 40 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See tomboy40 in Genome Data Viewer
Location:
42A14-42A14; 2-55 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6225634..6226884)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2113139..2114389)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene Tetratricopeptide repeat domain 7 Neighboring gene bicoid-interacting protein 3 Neighboring gene Phospholipase D Neighboring gene long non-coding RNA:CR46075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. Hwa JJ, et al. FEBS Lett, 2004 Aug 13. PMID 15304338
  2. An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Trinh I, et al. Mol Metab, 2019 Jan. PMID 30389349, Free PMC Article
  3. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article
  4. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
  5. The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. Singh N, et al. Dev Biol, 2011 Apr 1. PMID 21262214

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial outer membrane translocase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tomboy40
Names
CG8330-PA
dtomboy40
tomboy40-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6225634..6226884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136369.2 → NP_610213.1  tomboy40 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610213.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6L1, Q6NN68
    UniProtKB/TrEMBL
    H0RNC6
    Related
    FBpp0085338
    Conserved Domains (1) summary
    cd07305
    Location:53 → 340
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6L1.1 A1Z6L1

Gene LinkOut

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