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Bap170 Brahma associated protein 170kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35560, updated on 4-Jan-2025

Summary

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Official Symbol
Bap170provided by FlyBase
Official Full Name
Brahma associated protein 170kDprovided by FlyBase
Primary source
FLYBASE:FBgn0042085
Locus tag
Dmel_CG3274
See related
AllianceGenome:FB:FBgn0042085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BAP 170; bap170; BAP170; BcDNA:GH12174; CG3274; Dmel\CG3274; hfl
Summary
Predicted to enable DNA binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; positive regulation of DNA-templated transcription; and protein stabilization. Part of brahma complex. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Bap170 in Genome Data Viewer
Location:
42B2-42B2; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6636512..6642358)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2524017..2529863)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 16kD subunit 1 Neighboring gene Trap1 Neighboring gene Flavin-containing monooxygenase 2 Neighboring gene Death executioner Bcl-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription. Judd J, et al. Genes Dev, 2021 Jan 1. PMID 33303640, Free PMC Article
  2. Kinetic principles underlying pioneer function of GAGA transcription factor in live cells. Tang X, et al. Nat Struct Mol Biol, 2022 Jul. PMID 35835866, Free PMC Article
  3. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Costa AC, et al. Cell Death Dis, 2013 Jan 17. PMID 23328674, Free PMC Article
  4. Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control. Moshkin YM, et al. Mol Cell Biol, 2007 Jan. PMID 17101803, Free PMC Article
  5. MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes. Nikolenko JV, et al. Dokl Biochem Biophys, 2021 May. PMID 33689064

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
    Title: Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
  2. Bap170 participates instead in the negative regulation of EGFR signaling
    Title: Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling.
  3. BAP170 and BAP180 act redundantly to allow metamorphosis gene expression profiling of bap170 bap180 double mutants, showed that the PBAP complex regulates genes involved in tissue remodeling and immune system function.
    Title: Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.
  4. Results report the identification of two novel BRM complex-associated proteins: Drosophila Polybromo and BAP170, a conserved protein not described previously.
    Title: Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SWI/SNF superfamily-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of brahma complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
brahma associated protein 170kD
Names
Bap170-PA
CG3274-PA
half-life

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6636512..6642358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136372.4 → NP_610216.1  brahma associated protein 170kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6M0
    Related
    FBpp0085442
    Conserved Domains (2) summary
    pfam01388
    Location:69 → 152
    ARID; ARID/BRIGHT DNA binding domain
    pfam02257
    Location:677 → 761
    RFX_DNA_binding; RFX DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6M0 A1Z6M0
Q7KMJ0 Q7KMJ0

Gene LinkOut

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