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Zip42C.1 Zinc/iron regulated transporter-related protein 42C.1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35579, updated on 9-Dec-2024

Summary

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Official Symbol
Zip42C.1provided by FlyBase
Official Full Name
Zinc/iron regulated transporter-related protein 42C.1provided by FlyBase
Primary source
FLYBASE:FBgn0033096
Locus tag
Dmel_CG9428
See related
AllianceGenome:FB:FBgn0033096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg9428; CG9428; Dmel\CG9428; dzip1; dZip1; dZIP1; dZip42C.1; dZIP42C.1; Zip1; ZIP1; ZIP42C.1
Summary
Enables zinc ion transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; detoxification of zinc ion; and zinc ion import across plasma membrane. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC39A1 (solute carrier family 39 member 1); SLC39A2 (solute carrier family 39 member 2); and SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Zip42C.1 in Genome Data Viewer
Location:
42C6-42C6; 2-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6716342..6717707, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2603847..2605212, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chaski Neighboring gene long non-coding RNA:CR43611 Neighboring gene mir-4975 stem loop Neighboring gene Zinc/iron regulated transporter-related protein 42C.2 Neighboring gene hulk

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. Lang M, et al. PLoS Genet, 2012. PMID 22570624, Free PMC Article
  2. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Huang Y, et al. Cell Rep, 2014 Aug 7. PMID 25066125, Free PMC Article
  3. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Richards CD, et al. Biometals, 2015 Dec. PMID 26411574
  4. Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins. Mathews WR, et al. J Biol Chem, 2005 Jan 7. PMID 15509557
  5. Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding. Lapart JA, et al. Biochem Soc Trans, 2020 Jun 30. PMID 32491167

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila.
    Title: Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila.
  2. dZip1 and dZip2 are specific zinc transporters involved in dietary zinc absorption
    Title: Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation.
  3. Genetic manipulation of dZip1 to modulate its expression was accompanied by altered Amyloid beta peptides accumulation, resulting in changes in the neurodegeneration development, cognitive performance, and lifespan of the Alzheimer's disease flies
    Title: Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IC
Inferred by Curator
more info
 PubMed 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detoxification of zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular zinc ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Zinc/iron regulated transporter-related protein 42C.1
Names
CG9428-PA
Zinc/iron regulated transporter-related protein 1
Zinc/iron transporter-related protein 1
Zip42C.1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6716342..6717707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080368.4 → NP_525107.1  Zinc/iron regulated transporter-related protein 42C.1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZR2, Q7K9B7
    Related
    FBpp0085472
    Conserved Domains (1) summary
    pfam02535
    Location:21 → 336
    Zip; ZIP Zinc transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZR2 Q7JZR2
Q7K9B7 Q7K9B7

Gene LinkOut

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