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SdhB - Succinate dehydrogenase, subunit B (iron-sulfur)

Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa