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koi klaroid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35594, updated on 9-Dec-2024

Summary

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Official Symbol
koiprovided by FlyBase
Official Full Name
klaroidprovided by FlyBase
Primary source
FLYBASE:FBgn0265003
Locus tag
Dmel_CG44154
See related
AllianceGenome:FB:FBgn0265003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD11166; CG18584; CG3287; CG44154; Dmel\CG44154; Koi; n(2)09967
Old locus tag
Dmel_CG18584; Dmel_CG3287
Summary
Predicted to enable protein-membrane adaptor activity. Involved in double-strand break repair via homologous recombination and nuclear migration. Located in nuclear envelope; nuclear periphery; and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See koi in Genome Data Viewer
Location:
42D4-42D4; 2-55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6811019..6818199)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2698524..2705704)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase, subunit B (iron-sulfur) Neighboring gene uncharacterized protein Neighboring gene ubiquitin like Neighboring gene long non-coding RNA:CR44442 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LINC Complex Inhibits Excessive Chromatin Repression. Amiad Pavlov D, et al. Cells, 2023 Mar 18. PMID 36980273, Free PMC Article
  2. Mixing and Matching Chromosomes during Female Meiosis. Rubin T, et al. Cells, 2020 Mar 12. PMID 32178277, Free PMC Article
  3. Nucleus-dependent sarcomere assembly is mediated by the LINC complex. Auld AL, et al. Mol Biol Cell, 2016 Aug 1. PMID 27307582, Free PMC Article
  4. Drosophila emerins control LINC complex localization and transcription to regulate myonuclear position. Mandigo TR, et al. J Cell Sci, 2019 Oct 18. PMID 31548202
  5. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import. Commisso C, et al. J Mol Biol, 2008 Jan 25. PMID 18076903

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that mushroom body defect protein (Mud) co-localized with centromeres, Klarsicht protein and Klaroid protein.
    Title: Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.
  2. Germ line nuclear envelope localization of both Msp-100 and Klarsicht proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females.
    Title: The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis.
  3. Klaroid, a SUN protein that tethers klarsitch, is identified. Both klaroid and klarsicht are required for nuclear migration in differentiating neurons and in non-neural cells.
    Title: Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
klaroid
Names
CG44154-PA
CG44154-PB
CG44154-PC
CG44154-PD
CG44154-PE
CG44154-PF
koi-PA
koi-PB
koi-PC
koi-PD
koi-PE
koi-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6811019..6818199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273809.1 → NP_001260738.1  klaroid, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KEE4
    Conserved Domains (1) summary
    pfam07738
    Location:827 → 962
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. NM_165491.3 → NP_724502.1  klaroid, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6Q0, Q8MS42

  3. NM_001273810.1 → NP_001260739.1  klaroid, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260739.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KEE4
    Conserved Domains (1) summary
    pfam07738
    Location:827 → 962
    Sad1_UNC; Sad1 / UNC-like C-terminal

  4. NM_001273811.1 → NP_001260740.1  klaroid, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260740.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6Q0, Q8MS42

  5. NM_136396.4 → NP_610240.4  klaroid, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610240.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6Q1
    Conserved Domains (1) summary
    pfam07738
    Location:743 → 878
    Sad1_UNC; Sad1 / UNC-like C-terminal

  6. NM_165492.3 → NP_724503.2  klaroid, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724503.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZ58
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEE4.1 A0A0B4KEE4
A1Z6Q0 A1Z6Q0
A1Z6Q1 A1Z6Q1
A4UZ58 A4UZ58
Q8MS42 Q8MS42

Gene LinkOut

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