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Cyp6u1 Cytochrome P450 6u1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35608, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp6u1provided by FlyBase
Official Full Name
Cytochrome P450 6u1provided by FlyBase
Primary source
FLYBASE:FBgn0033121
Locus tag
Dmel_CG3567
See related
AllianceGenome:FB:FBgn0033121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6u1; CG3567; Dmel\CG3567
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; gonad; and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cyp6u1 in Genome Data Viewer
Location:
42E1-42E1; 2-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6971996..6975026, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2859501..2862531, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene missing-in-metastasis Neighboring gene Chemosensory protein B 42c Neighboring gene Chemosensory protein B 42a Neighboring gene pickpocket 25 Neighboring gene long non-coding RNA:CR44170 Neighboring gene long non-coding RNA:CR44171 Neighboring gene UFM1 specific peptidase 1 Neighboring gene visceral mesodermal armadillo-repeats

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Kasai S, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559957
  2. Genetic characterization of the Drosophila homologue of coronin. Bharathi V, et al. J Cell Sci, 2004 Apr 15. PMID 15090595
  3. Rethinking the ecdysteroid source during Drosophila pupal-adult development. Scanlan JL, et al. Insect Biochem Mol Biol, 2023 Jan. PMID 36481381
  4. Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster. Guan DL, et al. BMC Genomics, 2019 May 9. PMID 31072326, Free PMC Article
  5. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Additionally, RNA interference against RG-enriched cytochrome p450s Cyp6u1 and Cyp6g2 produced a lethal ecdysone deficiency and a juvenile hormone deficiency, respectively, flagging a critical role for these genes in hormone synthesis.
    Title: Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 6u1
Names
CG3567-PA
CG3567-PB
CG3567-PC
Cyp6u1-PA
Cyp6u1-PB
Cyp6u1-PC
cytochrome P450
NP_001286149.1
NP_001286150.1
NP_610252.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6971996..6975026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299221.1 → NP_001286150.1  cytochrome P450 6u1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286150.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9B9, Q9V979
    UniProtKB/TrEMBL
    A0A0B4LET2
    Conserved Domains (1) summary
    cl12078
    Location:38 → 475
    p450; Cytochrome P450

  2. NM_136408.4 → NP_610252.3  cytochrome P450 6u1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610252.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9B9, Q9V979
    UniProtKB/TrEMBL
    A0A0B4LET2
    Related
    FBpp0085516
    Conserved Domains (1) summary
    cl12078
    Location:38 → 475
    p450; Cytochrome P450

  3. NM_001299220.1 → NP_001286149.1  cytochrome P450 6u1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9B9, Q9V979
    UniProtKB/TrEMBL
    A0A0B4LET2
    Conserved Domains (1) summary
    cl12078
    Location:38 → 475
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LET2 A0A0B4LET2
Q9V979.3 Q9V979

Gene LinkOut

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