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Tsp42Ei Tetraspanin 42Ei [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35618, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp42Eiprovided by FlyBase
Official Full Name
Tetraspanin 42Eiprovided by FlyBase
Primary source
FLYBASE:FBgn0033130
Locus tag
Dmel_CG12843
See related
AllianceGenome:FB:FBgn0033130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12843; Dm.Tsp42Ei; Dmel\CG12843; Tsp42EI
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal apodeme; embryonic dorsal epidermis; and embryonic ventral apodeme. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tsp42Ei in Genome Data Viewer
Location:
42E5-42E5; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7035125..7036949)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2922630..2924454)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Eg Neighboring gene Tetraspanin 42Eh Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Tetraspanin 42Ej Neighboring gene Tetraspanin 42Ek

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila. Kemp C, et al. J Immunol, 2013 Jan 15. PMID 23255357, Free PMC Article
  2. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
  3. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
  4. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
  5. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin 42Ei
Names
CG12843-PA
CG12843-PB
Tsp42Ei-PA
Tsp42Ei-PB
tetraspanin 42E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7035125..7036949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078911.4 → NP_523635.2  tetraspanin 42Ei, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523635.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZW3, Q9NB12
    Related
    FBpp0088099
    Conserved Domains (3) summary
    cd03127
    Location:104 → 189
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:7 → 217
    Tetraspannin; Tetraspanin family
    cl12079
    Location:17 → 101
    DUF373; Domain of unknown function (DUF373)

  2. NM_001273827.1 → NP_001260756.1  tetraspanin 42Ei, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZW3, Q9NB12
    Conserved Domains (3) summary
    cd03127
    Location:104 → 189
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:7 → 217
    Tetraspannin; Tetraspanin family
    cl12079
    Location:17 → 101
    DUF373; Domain of unknown function (DUF373)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZW3 Q7JZW3
Q9NB12 Q9NB12

Gene LinkOut

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