Gadd45 Growth arrest and DNA damage-inducible 45 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gadd45provided by FlyBase
Official Full Name: Growth arrest and DNA damage-inducible 45provided by FlyBase
Primary source: FLYBASE:FBgn0033153
Locus tag: Dmel_CG11086
See related: AllianceGenome:FB:FBgn0033153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH70774; CG11086; D-GADD45; Dmel\CG11086; gadd45; GADD45; GG1086
Summary: Involved in JNK cascade and regulation of egg-laying behavior. Located in nucleus. Orthologous to several human genes including GADD45A (growth arrest and DNA damage inducible alpha) and GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 43A2-43A2; 2-55 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7249161..7250655)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3136666..3138160)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

D-GADD45 is required for proper regeneration of wing imaginal discs. Findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
Title: Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila.
These findings demonstrate that degradation of Gadd45 mRNA is the essential nonsense-mediated mRNA decay function and, surprisingly, that the surveillance of abnormal mRNAs by this pathway is not necessarily required for viability.
Title: Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability.
Overexpression of D-GADD45 in the Drosophila nervous system prolongs the median and maximum life span without deterioration of quality of life parameters.
Title: Geroprotective effects of activation of D-GADD45 DNA reparation gene in Drosophila melanogaster nervous system.
D-GADD45 overexpression in the nervous system is associated with delayed neurodegeneration.
Title: Gadd45 expression correlates with age dependent neurodegeneration in Drosophila melanogaster.
D-GADD45 expression is activated by most of the studied stress factors, and D-GADD45 overexpression resulted in an increase of stress resistance.
Title: The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance.
longevity of D. melanogaster with D-GADD45 overexpression is apparently due to more efficient recognition and repair of DNA damage, as the DNA comet assay showed that spontaneous DNA damage in larva neuroblasts is reduced with statistical significance
Title: Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system.
Gadd45 gene is up-regulated in the Drosophila repair model.
Title: Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.
eggshell polarity defects caused by D-GADD45 overexpression were dominantly suppressed by mutations in the JNK pathway, suggesting that the JNK pathway has a novel, D-GADD45-mediated, function in the germline
Title: Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info