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cdgs-1 Phosphatidate cytidylyltransferase [ Caenorhabditis elegans ]

Gene ID: 3565046, updated on 2-Nov-2024

Summary

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Official Symbol
cdgs-1
Official Full Name
Phosphatidate cytidylyltransferase
Primary source
WormBase:WBGene00016384
Locus tag
CELE_C33H5.18
See related
AllianceGenome:WB:WBGene00016384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and tail. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdgs-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (7812908..7815733, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene Zinc finger CCCH-type with G patch domain-containing protein Neighboring gene ncRNA Neighboring gene Resistance to inhibitors of cholinesterase protein 3 Neighboring gene MS Related Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase. Wu L, et al. Nature, 1995 Jan 19. PMID 7816135
  2. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
  3. Intracellular lipid surveillance by small G protein geranylgeranylation. Watterson A, et al. Nature, 2022 May. PMID 35585236, Free PMC Article
  4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phosphatidate cytidylyltransferase
NP_501297.1
  • Confirmed by transcript evidence
NP_501298.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7812908..7815733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068897.5 → NP_501298.1  Phosphatidate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501298.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G8JY50, P53439
    Conserved Domains (1) summary
    cl21502
    Location:147 → 443
    CTP_transf_1; Cytidylyltransferase family

  2. NM_068896.7 → NP_501297.1  Phosphatidate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53439
    Conserved Domains (1) summary
    cl21502
    Location:137 → 433
    CTP_transf_1; Cytidylyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53439.2

Gene LinkOut

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