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fce-2 CAAX prenyl protease 2 [ Caenorhabditis elegans ]

Gene ID: 3565253, updated on 9-Dec-2024

Summary

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Official Symbol
fce-2
Official Full Name
CAAX prenyl protease 2
Primary source
WormBase:WBGene00001406
Locus tag
CELE_F48F5.5
See related
AllianceGenome:WB:WBGene00001406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cysteine-type endopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fce-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (20425301..20431297)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene ncRNA Neighboring gene WW domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Cadiñanos J, et al. Biochem J, 2003 Mar 15. PMID 12487630, Free PMC Article
  2. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
  3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that CeFACE-1 and CeFACE-2 are bona fide CaaX proteases and support the evolutionary conservation of this proteolytic system in eukaryotes.
    Title: Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAAX-box protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAAX-box protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CAAX-box protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CAAX prenyl protease 2
NP_001023947.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20425301..20431297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028776.4 → NP_001023947.1  CAAX prenyl protease 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023947.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEP3
    Conserved Domains (1) summary
    pfam02517
    Location:118 → 221
    Abi; CAAX protease self-immunity
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEP3.1

Gene LinkOut

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