sta-2 Signal transducer and activator of transcription b [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sta-2
Official Full Name: Signal transducer and activator of transcription b
Primary source: WormBase:WBGene00010251
Locus tag: CELE_F58E6.1
See related: AllianceGenome:WB:WBGene00010251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Is expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT1 (signal transducer and activator of transcription 1); STAT3 (signal transducer and activator of transcription 3); and STAT4 (signal transducer and activator of transcription 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sta-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (9741206..9744331)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.
Title: Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.
The authors identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate antimicrobial peptide gene expression in the epidermis.
Title: Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
The association between STA-2 and hemidesmosomes enabled the epidermis to quickly respond to extensive physical damage without the need to go through multiple signaling cascades.
Title: Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58E6.1 (e-PCR)
- UniSTS:312371

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antifungal peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
part_of hemidesmosome associated protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Signal transducer and activator of transcription b

NP_001122963.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9741206..9744331

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129491.3 → NP_001122963.1 Signal transducer and activator of transcription b [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122963.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2D6L5, Q20977, Q20978, Q95ZS4, Q9U9L4

Conserved Domains (2) summary

cd09919
Location:433 → 545

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam02864
Location:167 → 359

STAT_bind; STAT protein, DNA binding domain