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max-2 Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

Gene ID: 3565400, updated on 4-Jan-2025

Summary

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Official Symbol
max-2
Official Full Name
Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase
Primary source
WormBase:WBGene00003144
Locus tag
CELE_Y38F1A.10
See related
AllianceGenome:WB:WBGene00003144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including gonad morphogenesis; inductive cell migration; and netrin-activated signaling pathway. Predicted to be located in dendrite and perikaryon. Predicted to be active in cytoplasm. Is expressed in neurons; pharynx; and ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See max-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (13014317..13025844, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Core Molecular Machinery Used for Engulfment of Apoptotic Cells Regulates the JNK Pathway Mediating Axon Regeneration in Caenorhabditis elegans. Pastuhov SI, et al. J Neurosci, 2016 Sep 14. PMID 27629720, Free PMC Article
  2. Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations. Peters EC, et al. G3 (Bethesda), 2013 Feb. PMID 23390595, Free PMC Article
  3. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. Ito TK, et al. PLoS One, 2014. PMID 25057989, Free PMC Article
  4. CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin. Quinn CC, et al. Curr Biol, 2008 Jun 3. PMID 18499456, Free PMC Article
  5. CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans. Tannoury H, et al. Dev Biol, 2010 May 1. PMID 20188721, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAX-2 functions downstream of the UNC-6/netrin receptor UNC-5 during axon repulsion and is an integral part of its signaling.
    Title: The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.
  2. results suggest that MAX-2 and MIG-2 play a crucial role in mediating the heavy metal stress response regulated by the KGB-1 pathway.
    Title: The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gonad morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in inductive cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in netrin-activated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase
NP_001076635.1
  • Confirmed by transcript evidence
NP_001076636.1
  • Confirmed by transcript evidence
NP_001122655.1
  • Confirmed by transcript evidence
NP_001254363.1
  • Confirmed by transcript evidence
NP_001300485.1
  • Confirmed by transcript evidence
NP_001300486.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13014317..13025844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083167.2 → NP_001076636.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGQ3
    Conserved Domains (2) summary
    smart00220
    Location:156 → 407
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06614
    Location:155 → 408
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

  2. NM_001129183.4 → NP_001122655.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGQ3, G5EGS0, H2KMK1, Q9XWL8
    Conserved Domains (2) summary
    cd06614
    Location:375 → 628
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
    pfam00786
    Location:40 → 94
    PBD; P21-Rho-binding domain

  3. NM_001313556.2 → NP_001300485.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQV8
    Conserved Domains (2) summary
    smart00220
    Location:379 → 630
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06614
    Location:378 → 631
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

  4. NM_001083166.5 → NP_001076635.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGQ3
    Conserved Domains (2) summary
    smart00220
    Location:328 → 579
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06614
    Location:327 → 580
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

  5. NM_001313557.3 → NP_001300486.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUE7
    Conserved Domains (2) summary
    cd06614
    Location:330 → 583
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
    pfam00786
    Location:40 → 97
    PBD; P21-Rho-binding domain

  6. NM_001267434.3 → NP_001254363.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254363.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGQ3
    Conserved Domains (2) summary
    smart00220
    Location:1 → 250
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06614
    Location:3 → 251
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGQ3.1

Gene LinkOut

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