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spe-10 Palmitoyltransferase spe-10 [ Caenorhabditis elegans ]

Gene ID: 3565514, updated on 9-Dec-2024

Summary

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Official Symbol
spe-10
Official Full Name
Palmitoyltransferase spe-10
Primary source
WormBase:WBGene00004964
Locus tag
CELE_AC3.10
See related
AllianceGenome:WB:WBGene00004964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including amoeboid sperm motility; positive regulation of cell size; and pseudopodium organization. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spe-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (10384250..10385740)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene Aminopeptidase;Aminopeptidase-like protein AC3.5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. spe-10 encodes a DHHC-CRD zinc-finger membrane protein required for endoplasmic reticulum/Golgi membrane morphogenesis during Caenorhabditis elegans spermatogenesis. Gleason EJ, et al. Genetics, 2006 Jan. PMID 16143610, Free PMC Article
  2. The spe-10 mutant has longer life and increased stress resistance. Cypser JR, et al. Neurobiol Aging, 1999 Sep-Oct. PMID 10638523
  3. The effects of Microcystis aeruginosa cells lysate containing microcystins on physiological and molecular responses in the nematode Caenorhabditis elegans. Sopezki MS, et al. Environ Toxicol, 2020 May. PMID 31916382
  4. Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. Li Y, et al. Int J Mol Sci, 2015 Sep 22. PMID 26402677, Free PMC Article
  5. Mutations that disrupt the morphogenesis and localization of a sperm-specific organelle in Caenorhabditis elegans. Shakes DC, et al. Dev Biol, 1989 Aug. PMID 2744235

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amoeboid sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pseudopodium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Palmitoyltransferase spe-10
NP_001021339.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10384250..10385740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026168.5 → NP_001021339.1  Palmitoyltransferase spe-10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5FC64
    Conserved Domains (1) summary
    pfam01529
    Location:151 → 277
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FC64.1

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