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npl-4.2 Nuclear protein localization protein 4 homolog 2 [ Caenorhabditis elegans ]

Gene ID: 3565577, updated on 4-Jan-2025

Summary

Official Symbol
npl-4.2
Official Full Name
Nuclear protein localization protein 4 homolog 2
Primary source
WormBase:WBGene00019121
Locus tag
CELE_F59E12.5
See related
AllianceGenome:WB:WBGene00019121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Involved in ERAD pathway and embryo development. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See npl-4.2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (5622889..5624959)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Hydroxysteroid dehydrogenase-like protein 2 Neighboring gene Eukaryotic translation initiation factor 3 subunit L Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Nuclear protein localization protein 4 homolog 1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Nuclear protein localization protein 4 homolog 2
NP_001370454.1
  • Confirmed by transcript evidence
NP_495093.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5622889..5624959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062692.5NP_495093.1  Nuclear protein localization protein 4 homolog 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01894, Q95QZ9
    Conserved Domains (4) summary
    smart00547
    Location:504526
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:504523
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:13148
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:151470
    NPL4; NPL4 family
  2. NM_001383842.1NP_001370454.1  Nuclear protein localization protein 4 homolog 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (4) summary
    smart00547
    Location:502524
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:502521
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:13148
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:151470
    NPL4; NPL4 family