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noca-1 Non-centrosomal microtubule array protein 1 [ Caenorhabditis elegans ]

Gene ID: 3565610, updated on 4-Jan-2025

Summary

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Official Symbol
noca-1
Official Full Name
Non-centrosomal microtubule array protein 1
Primary source
WormBase:WBGene00011647
Locus tag
CELE_T09E8.1
See related
AllianceGenome:WB:WBGene00011647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cytoplasmic microtubule organization; germ cell development; and nematode larval development. Located in microtubule. Is expressed in hyp7 syncytium and intestinal cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See noca-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
21
Sequence:
Chromosome: V; NC_003283.11 (13152919..13176115)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cubilin Neighboring gene Dynein Heavy Chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene High Incidence of Males (increased X chromosome loss) Neighboring gene Protein cornichon homolog 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation. Quintin S, et al. Development, 2016 Jan 1. PMID 26586219, Free PMC Article
  2. NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. Wang S, et al. Elife, 2015 Sep 15. PMID 26371552, Free PMC Article
  3. PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites. He L, et al. PLoS Biol, 2022 Nov. PMID 36395330, Free PMC Article
  4. Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules. Castiglioni VG, et al. Elife, 2020 Dec 10. PMID 33300872, Free PMC Article
  5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Non-centrosomal microtubule array protein 1
NP_001041165.1
  • Partially confirmed by transcript evidence
NP_001303706.1
  • Confirmed by transcript evidence
NP_001370898.1
  • Partially confirmed by transcript evidence
NP_506274.1
  • Partially confirmed by transcript evidence
NP_506275.2
  • Partially confirmed by transcript evidence
NP_506276.2
  • Partially confirmed by transcript evidence
NP_872199.2
  • Partially confirmed by transcript evidence
NP_872200.1
  • Partially confirmed by transcript evidence
NP_872201.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13152919..13176115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316777.4 → NP_001303706.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    COG1196
    Location:514 → 728
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_073873.3 → NP_506274.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3

  3. NM_001383436.1 → NP_001370898.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    COG1196
    Location:187 → 401
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_182399.8 → NP_872199.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872199.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0M3UPV7, G5EBN2, G5EBP7, G5EC74, G5EE58, G5EEK3, N1NSE8, Q8I4G1, Q9XVL5
    Conserved Domains (2) summary
    pfam15619
    Location:567 → 727
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl03075
    Location:612 → 698
    GrpE; nucleotide exchange factor GrpE

  5. NM_001047700.5 → NP_001041165.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    pfam01496
    Location:338 → 477
    V_ATPase_I; V-type ATPase 116kDa subunit family

  6. NM_073874.7 → NP_506275.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506275.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    pfam01496
    Location:336 → 475
    V_ATPase_I; V-type ATPase 116kDa subunit family

  7. NM_073875.5 → NP_506276.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506276.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    pfam01496
    Location:394 → 533
    V_ATPase_I; V-type ATPase 116kDa subunit family

  8. NM_182401.5 → NP_872201.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872201.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    pfam01496
    Location:194 → 333
    V_ATPase_I; V-type ATPase 116kDa subunit family

  9. NM_182400.7 → NP_872200.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEK3
    Conserved Domains (1) summary
    pfam01496
    Location:194 → 333
    V_ATPase_I; V-type ATPase 116kDa subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEK3.1

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