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aakg-1 CBS domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3565679, updated on 9-Dec-2024

Summary

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Official Symbol
aakg-1
Official Full Name
CBS domain-containing protein
Primary source
WormBase:WBGene00013732
Locus tag
CELE_Y111B2A.8
See related
AllianceGenome:WB:WBGene00013732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in labial sensillum and nervous system. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aakg-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (12538664..12575401, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GRIP domain-containing protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Enhancer of polycomb-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allosteric regulation of C. elegans AMP-activated protein kinase. Scanlon DM, et al. MicroPubl Biol, 2022. PMID 35622498, Free PMC Article
  2. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CBS domain-containing protein
NP_001368614.1
  • Confirmed by transcript evidence
NP_001368615.1
  • Confirmed by transcript evidence
NP_001368616.1
  • Confirmed by transcript evidence
NP_001368617.1
  • Confirmed by transcript evidence
NP_001368643.1
  • Confirmed by transcript evidence
NP_001368644.1
  • Confirmed by transcript evidence
NP_001370107.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12538664..12575401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379957.2 → NP_001368615.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I6CM91
    Conserved Domains (2) summary
    cd04618
    Location:357 → 497
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:524 → 646
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  2. NM_001379958.3 → NP_001368616.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I6CM90
    Conserved Domains (2) summary
    cd04618
    Location:354 → 494
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:521 → 643
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  3. NM_001383011.2 → NP_001370107.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BHL6
    Conserved Domains (2) summary
    cd04618
    Location:215 → 355
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:382 → 504
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  4. NM_001379956.1 → NP_001368643.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUK9
    Conserved Domains (2) summary
    cd04618
    Location:434 → 574
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:601 → 723
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  5. NM_001379959.1 → NP_001368644.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUL8
    Conserved Domains (2) summary
    cd04618
    Location:116 → 256
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:283 → 405
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  6. NM_001379960.1 → NP_001368617.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I6CMB9
    Conserved Domains (2) summary
    cd04618
    Location:89 → 229
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:256 → 378
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  7. NM_001379961.1 → NP_001368614.1  CBS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I6CM85
    Conserved Domains (2) summary
    cd04618
    Location:5 → 145
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:172 → 294
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
Nucleotide Protein
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