hrpl-1 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hrpl-1
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00016624
Locus tag: CELE_C44B7.2
See related: AllianceGenome:WB:WBGene00016624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to several human genes including HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hrpl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (6898736..6901722)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44B7.2 (e-PCR)
- UniSTS:305596

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RRM domain-containing protein

NP_001379559.1

Confirmed by transcript evidence

NP_495412.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6898736..6901722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393108.1 → NP_001379559.1 RRM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95QR5

Conserved Domains (1) summary

TIGR01649
Location:30 → 514

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_063011.6 → NP_495412.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495412.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95QR6

Conserved Domains (3) summary

cd12689
Location:30 → 109

RRM1_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:120 → 206

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cl17169
Location:289 → 318

RRM_SF; RNA recognition motif (RRM) superfamily