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fitm-2 Acyl-coenzyme A diphosphatase FITM2 [ Caenorhabditis elegans ]

Gene ID: 3565961, updated on 9-Dec-2024

Summary

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Official Symbol
fitm-2
Official Full Name
Acyl-coenzyme A diphosphatase FITM2
Primary source
WormBase:WBGene00044094
Locus tag
CELE_ZK265.9
See related
AllianceGenome:WB:WBGene00044094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable coenzyme A diphosphatase activity. Involved in lipid droplet formation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to several human genes including FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fitm-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (8253456..8254926, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Homeobox domain-containing protein;Homeobox protein ceh-8 Neighboring gene Nucleolar protein 16 Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Keeping FIT, storing fat: Lipid droplet biogenesis. Choudhary V, et al. Worm, 2016 Apr-Jun. PMID 27383728, Free PMC Article
  2. A conserved family of proteins facilitates nascent lipid droplet budding from the ER. Choudhary V, et al. J Cell Biol, 2015 Oct 26. PMID 26504167, Free PMC Article
  3. Evolutionarily conserved gene family important for fat storage. Kadereit B, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18160536, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables coenzyme A diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables coenzyme A diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty-acyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Acyl-coenzyme A diphosphatase FITM2
NP_001021865.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8253456..8254926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026694.7 → NP_001021865.1  Acyl-coenzyme A diphosphatase FITM2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5CZ37
    Conserved Domains (1) summary
    pfam10261
    Location:75 → 263
    Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5CZ37.1

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