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parp-2 Poly [ADP-ribose] polymerase 2 [ Caenorhabditis elegans ]

Gene ID: 3565967, updated on 14-Nov-2024

Summary

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Official Symbol
parp-2
Official Full Name
Poly [ADP-ribose] polymerase 2
Primary source
WormBase:WBGene00004050
Locus tag
CELE_E02H1.4
See related
AllianceGenome:WB:WBGene00004050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in double-strand break repair and protein poly-ADP-ribosylation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See parp-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (9593037..9595128)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative dimethyladenosine transferase Neighboring gene putative tRNA pseudouridine synthase tag-124 Neighboring gene Uncharacterized protein Neighboring gene Adenylate kinase isoenzyme 6 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans. Neumann C, et al. J Trace Elem Med Biol, 2020 Jan. PMID 31546209, Free PMC Article
  2. Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival. Dequen F, et al. DNA Repair (Amst), 2005 Jul 12. PMID 15923155
  3. The C. elegans gene pme-5: molecular cloning and role in the DNA-damage response of a tankyrase orthologue. Gravel C, et al. DNA Repair (Amst), 2004 Feb 3. PMID 14706351
  4. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
  5. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Poly [ADP-ribose] polymerase 2
NP_001022057.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9593037..9595128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026886.6 → NP_001022057.1  Poly [ADP-ribose] polymerase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09525
    Conserved Domains (3) summary
    smart00773
    Location:7 → 89
    WGR; Proposed nucleic acid binding domain
    cd01437
    Location:155 → 527
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:304 → 527
    PARP; Poly(ADP-ribose) polymerase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09525.1

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