U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

p47 p47 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35674, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
p47provided by FlyBase
Official Full Name
p47provided by FlyBase
Primary source
FLYBASE:FBgn0033179
Locus tag
Dmel_CG11139
See related
AllianceGenome:FB:FBgn0033179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.216; CG11139; Dmel\CG11139; dp47; P47
Summary
Predicted to enable ubiquitin binding activity. Involved in nuclear membrane reassembly and rhabdomere development. Located in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See p47 in Genome Data Viewer
Location:
43C3-43C4; 2-56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7465018..7466759, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3352523..3354264, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase type III Neighboring gene wech

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
  2. RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. Wójcik C, et al. J Cell Sci, 2004 Jan 15. PMID 14657277
  3. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
  4. Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Sang TK, et al. Development, 2002 Jan. PMID 11782408
  5. Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation. Zhang Z, et al. Dev Cell, 2013 Jun 24. PMID 23747190

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
p47
Names
CG11139-PA
p47 a
p47-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7465018..7466759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136440.6 → NP_610284.1  p47 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z3
    Related
    FBpp0088069
    Conserved Domains (3) summary
    cd01770
    Location:329 → 407
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:211 → 300
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
    cd14672
    Location:6 → 42
    UBA_ceTYDP2_like; UBA-like domain found in Caenorhabditis elegans tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3Z3 Q7K3Z3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous