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Rpe Ribulose-5-phosphate-3-epimerase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35692, updated on 9-Dec-2024

Summary

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Official Symbol
Rpeprovided by FlyBase
Official Full Name
Ribulose-5-phosphate-3-epimeraseprovided by FlyBase
Primary source
FLYBASE:FBgn0050499
Locus tag
Dmel_CG30499
See related
AllianceGenome:FB:FBgn0050499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1364; CG30499; Dmel\CG30499
Summary
Enables D-ribulose-phosphate 3-epimerase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be active in cytosol. Is expressed in adult head and organism. Orthologous to several human genes including RPEL1 (ribulose-5-phosphate-3-epimerase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rpe in Genome Data Viewer
Location:
43D7-43D7; 2-56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7564434..7565751, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3451939..3453256, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2 Neighboring gene uncharacterized protein Neighboring gene corin Neighboring gene boca Neighboring gene Vacuolar protein sorting 13 Neighboring gene antisense RNA:CR45130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficient Drosophila melanogaster. Geer BW, et al. J Exp Zool, 1974 Jan. PMID 4149211
  2. Chromosomal instability causes sensitivity to protein folding stress and ATP depletion. Khan M, et al. Biol Open, 2018 Oct 16. PMID 30327366, Free PMC Article
  3. Potential involvement of Drosophila flightless-1 in carbohydrate metabolism. Park JE, et al. BMB Rep, 2018 Sep. PMID 30060781, Free PMC Article
  4. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article
  5. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-ribulose-phosphate 3-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ribulose-5-phosphate-3-epimerase
Names
CG30499-PA
CG30499-PB
Rpe-PA
Rpe-PB
ribulose phosphate 3-epimerase
NP_001260780.1
NP_610298.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7564434..7565751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136454.3 → NP_610298.2  Ribulose-5-phosphate-3-epimerase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610298.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RV5
    Related
    FBpp0088028
    Conserved Domains (1) summary
    cd00429
    Location:6 → 213
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  2. NM_001273851.1 → NP_001260780.1  Ribulose-5-phosphate-3-epimerase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RV5
    Conserved Domains (1) summary
    cd00429
    Location:6 → 213
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RV5 Q95RV5

Gene LinkOut

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