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M7BP Myosin-7a binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35698, updated on 9-Dec-2024

Summary

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Official Symbol
M7BPprovided by FlyBase
Official Full Name
Myosin-7a binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263077
Locus tag
Dmel_CG43340
See related
AllianceGenome:FB:FBgn0263077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH02712; BcDNA:HL07907; CG17983; CG17984; CG2080; CG2088; CG30492; CG30494; CG43340; CT6764; Dmel\CG43340
Old locus tag
Dmel_CG30492; Dmel_CG30494
Summary
Enables ATPase activator activity and myosin binding activity. Involved in filopodium assembly. Located in cytosol. Colocalizes with actin cytoskeleton. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See M7BP in Genome Data Viewer
Location:
43E5-43E7; 2-57 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7623242..7651787)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3510747..3539292)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Histamine transporter Neighboring gene long non-coding RNA:CR44444 Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A binding protein regulates myosin-7a dimerization and actin bundle assembly. Liu R, et al. Nat Commun, 2021 Jan 25. PMID 33495456, Free PMC Article
  2. Genetic screen for genes involved in Chk2 signaling in Drosophila. Park SY, et al. Mol Cells, 2008 Oct 31. PMID 18612247
  3. Control of daily transcript oscillations in Drosophila by light and the circadian clock. Wijnen H, et al. PLoS Genet, 2006 Mar. PMID 16565745, Free PMC Article
  4. Gene-by-temperature interactions and candidate plasticity genes for morphological traits in Drosophila melanogaster. Carreira VP, et al. PLoS One, 2013. PMID 23936253, Free PMC Article
  5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in filopodium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Myosin-7a binding protein
Names
CG43340-PA
CG43340-PC
CG43340-PD
CG43340-PE
CG43340-PF
CG43340-PG
CG43340-PH
CG43340-PJ
CG43340-PK
CG43340-PL
CG43340-PM
CG43340-PN
CG43340-PO
CG43340-PP
CG43340-PQ
M7BP-PA
M7BP-PC
M7BP-PD
M7BP-PE
M7BP-PF
M7BP-PG
M7BP-PH
M7BP-PJ
M7BP-PK
M7BP-PL
M7BP-PM
M7BP-PN
M7BP-PO
M7BP-PP
M7BP-PQ
myosin-7a binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7623242..7651787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259256.2 → NP_001246185.1  Myosin-7a binding protein, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246185.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z718, Q8MQX7
    Conserved Domains (1) summary
    cd15751
    Location:100 → 156
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  2. NM_176100.2 → NP_788280.1  Myosin-7a binding protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788280.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z718, Q8MQX7
    Conserved Domains (1) summary
    cd15751
    Location:100 → 156
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  3. NM_001103740.3 → NP_001097210.2  Myosin-7a binding protein, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097210.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY53, F3YDQ1
    Conserved Domains (1) summary
    cd15751
    Location:100 → 156
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  4. NM_176101.3 → NP_788281.1  Myosin-7a binding protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788281.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z719, F3YDQ1
    Conserved Domains (1) summary
    cd15751
    Location:100 → 156
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  5. NM_170613.3 → NP_724586.2  Myosin-7a binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724586.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z720, Q8MQX7
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  6. NM_170614.3 → NP_724587.2  Myosin-7a binding protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724587.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z720, Q8MQX7
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  7. NM_001273853.1 → NP_001260782.1  Myosin-7a binding protein, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU21, Q95R83
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  8. NM_001259255.1 → NP_001246184.1  Myosin-7a binding protein, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7U0
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  9. NM_001259257.1 → NP_001246186.1  Myosin-7a binding protein, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246186.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K702
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  10. NM_136458.3 → NP_610302.3  Myosin-7a binding protein, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610302.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z722
    Conserved Domains (1) summary
    cd15751
    Location:63 → 119
    FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

  11. NM_001259258.2 → NP_001246187.1  Myosin-7a binding protein, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z721, Q95R83
    Conserved Domains (1) summary
    PHA03307
    Location:441 → 611
    PHA03307; transcriptional regulator ICP4; Provisional

  12. NM_001259259.2 → NP_001246188.1  Myosin-7a binding protein, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z721, Q95R83
    Conserved Domains (1) summary
    PHA03307
    Location:441 → 611
    PHA03307; transcriptional regulator ICP4; Provisional

  13. NM_001259260.1 → NP_001246189.1  Myosin-7a binding protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7U2, D0Z771
    Conserved Domains (1) summary
    PHA03307
    Location:565 → 735
    PHA03307; transcriptional regulator ICP4; Provisional

  14. NM_176102.3 → NP_788282.1  Myosin-7a binding protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788282.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z721, Q95R83
    Conserved Domains (1) summary
    PHA03307
    Location:441 → 611
    PHA03307; transcriptional regulator ICP4; Provisional

  15. NM_001273854.1 → NP_001260783.1  Myosin-7a binding protein, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEE5
    Conserved Domains (2) summary
    PRK10811
    Location:1920 → 2090
    rne; ribonuclease E; Reviewed
    PRK14949
    Location:1360 → 1738
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K702 A0A0B4K702
A0A0B4K7U0 A0A0B4K7U0
A0A0B4K7U2 A0A0B4K7U2
A0A0B4KEE5 A0A0B4KEE5
A1Z718 A1Z718
A1Z719 A1Z719
A1Z720 A1Z720
A1Z721 A1Z721
A1Z722 A1Z722
A8DY53 A8DY53
G4LU21 G4LU21

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