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CG17985 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35702, updated on 9-Dec-2024

Summary

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Official Symbol
CG17985provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033199
Locus tag
Dmel_CG17985
See related
AllianceGenome:FB:FBgn0033199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17985
Summary
Enables peptidoglycan binding activity. Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in Golgi membrane. Is expressed in adult head. Orthologous to several human genes including LYSMD3 (LysM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG17985 in Genome Data Viewer
Location:
43E7-43E7; 2-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7651625..7655302, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3539130..3542807, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44444 Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695
  2. Peptidoglycan recognition in Drosophila is mediated by LysMD3/4. Snee M, et al. J Biol Chem, 2023 Jun. PMID 37116706, Free PMC Article
  3. Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations. Mateo L, et al. Sci Rep, 2018 Nov 1. PMID 30385770, Free PMC Article
  4. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article
  5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peptidoglycan recognition in Drosophila is mediated by LysMD3/4.
    Title: Peptidoglycan recognition in Drosophila is mediated by LysMD3/4.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG17985-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7651625..7655302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136461.4 → NP_610305.1  uncharacterized protein Dmel_CG17985 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4J7
    Related
    FBpp0088020
    Conserved Domains (2) summary
    COG1388
    Location:60 → 105
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:59 → 102
    LysM; LysM domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K4J7 Q7K4J7

Gene LinkOut

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