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CG30491 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35704, updated on 4-Jan-2025

Summary

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Official Symbol
CG30491provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050491
Locus tag
Dmel_CG30491
See related
AllianceGenome:FB:FBgn0050491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17986; CG2074; Dmel\CG30491
Summary
Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland; and salivary gland body primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG30491 in Genome Data Viewer
Location:
43E7-43E7; 2-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7655072..7656770)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3542577..3544275)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
  2. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746
  3. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG30491-PA
CG30491-PB
NP_001260784.1
NP_610306.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7655072..7656770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136462.2 → NP_610306.1  uncharacterized protein Dmel_CG30491, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUS1
    Related
    FBpp0087993
    Conserved Domains (2) summary
    PRK06197
    Location:43 → 323
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:45 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001273855.1 → NP_001260784.1  uncharacterized protein Dmel_CG30491, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JUS1
    Conserved Domains (2) summary
    PRK06197
    Location:43 → 323
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:45 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JUS1 Q7JUS1

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