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CG2070 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35706, updated on 9-Dec-2024

Summary

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Official Symbol
CG2070provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033203
Locus tag
Dmel_CG2070
See related
AllianceGenome:FB:FBgn0033203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2070
Summary
Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG2070 in Genome Data Viewer
Location:
43E8-43E8; 2-57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7661855..7663408)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3549360..3550913)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene Dynactin 4, p62 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
  2. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
  3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
  4. Heat-shock promoters: targets for evolution by P transposable elements in Drosophila. Walser JC, et al. PLoS Genet, 2006 Oct 6. PMID 17029562, Free PMC Article
  5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG2070-PA
CG2070-PB
NP_001260786.1
NP_610308.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7661855..7663408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273857.1 → NP_001260786.1  uncharacterized protein Dmel_CG2070, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZG9, Q9V4Q1
    Conserved Domains (2) summary
    PRK06197
    Location:41 → 323
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:43 → 317
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_136464.2 → NP_610308.2  uncharacterized protein Dmel_CG2070, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610308.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZG9, Q9V4Q1
    Related
    FBpp0087995
    Conserved Domains (2) summary
    PRK06197
    Location:41 → 323
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:43 → 317
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MZG9 Q8MZG9

Gene LinkOut

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