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DCTN4-p62 Dynactin 4, p62 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35709, updated on 9-Dec-2024

Summary

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Official Symbol
DCTN4-p62provided by FlyBase
Official Full Name
Dynactin 4, p62 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0033206
Locus tag
Dmel_CG12042
See related
AllianceGenome:FB:FBgn0033206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12042; DCTN4; Dmel\CG12042; p62; P62
Summary
Predicted to be part of dynactin complex. Is expressed in adult head and organism. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See DCTN4-p62 in Genome Data Viewer
Location:
43E9-43E9; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7667248..7669029, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3554753..3556534, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diamond controls epithelial polarity through the dynactin-dynein complex. Zhao H, et al. Traffic, 2023 Dec. PMID 37642208
  2. Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models. Anderson EN, et al. Hum Mol Genet, 2018 Apr 15. PMID 29432563, Free PMC Article
  3. p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies. Saitoh Y, et al. J Biol Chem, 2015 Jan 16. PMID 25480790, Free PMC Article
  4. Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw. Lee J, et al. Development, 2015 Jan 1. PMID 25480915, Free PMC Article
  5. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Traumatic brain injury leads to ubiquitinated p62 stress granules in frontotemporal dementia-amyotrophic lateral sclerosis Drosophila model.
    Title: Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.
  2. p62 plays a protective role against polyQ-induced neurodegeneration, by the autophagic degradation of polyQ protein oligomers in vivo
    Title: p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynactin 4, p62 subunit
Names
CG12042-PA
DCTN4-p62-PA
Dynactin4 p62
P62 DYNACTIN
p62 subunit of dynactin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7667248..7669029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136467.3 → NP_610311.1  dynactin 4, p62 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K130
    Related
    FBpp0088018
    Conserved Domains (1) summary
    pfam05502
    Location:20 → 363
    Dynactin_p62; Dynactin p62 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K130 Q7K130

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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