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CG1941 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35718, updated on 9-Dec-2024

Summary

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Official Symbol
CG1941provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033214
Locus tag
Dmel_CG1941
See related
AllianceGenome:FB:FBgn0033214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1941
Summary
Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG1941 in Genome Data Viewer
Location:
43E12-43E12; 2-57 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7709873..7711981)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3597378..3599486)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene torso Neighboring gene mir-4909 stem loop Neighboring gene Diacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Konikoff CE, et al. Dev Dyn, 2012 Jan. PMID 21960044, Free PMC Article
  2. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article
  3. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article
  4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
  5. Drosophila model for studying the link between lipid metabolism and development. Thanh MT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585882

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1941-PA
CG1941-PB
CG1941-PC
CG1941-PD
NP_001286161.1
NP_001286162.1
NP_001286163.1
NP_610317.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7709873..7711981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299233.1 → NP_001286162.1  uncharacterized protein Dmel_CG1941, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYK2
    Conserved Domains (1) summary
    cl17185
    Location:50 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  2. NM_001299232.1 → NP_001286161.1  uncharacterized protein Dmel_CG1941, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYK2
    Conserved Domains (1) summary
    cl17185
    Location:50 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  3. NM_136473.3 → NP_610317.1  uncharacterized protein Dmel_CG1941, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610317.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYK2
    Related
    FBpp0088001
    Conserved Domains (1) summary
    cl17185
    Location:50 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  4. NM_001299234.1 → NP_001286163.1  uncharacterized protein Dmel_CG1941, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYK2
    Conserved Domains (1) summary
    cl17185
    Location:50 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JYK2 Q7JYK2

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