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TTLL12 Tubulin tyrosine ligase-like 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35732, updated on 9-Dec-2024

Summary

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Official Symbol
TTLL12provided by FlyBase
Official Full Name
Tubulin tyrosine ligase-like 12provided by FlyBase
Primary source
FLYBASE:FBgn0033225
Locus tag
Dmel_CG1550
See related
AllianceGenome:FB:FBgn0033225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1550; DmCG1550; Dmel\CG1550
Summary
Predicted to enable protein-glycine ligase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See TTLL12 in Genome Data Viewer
Location:
43E18-43E18; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7810068..7812028, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3697573..3699533, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase zeta subunit 1 Neighboring gene Nop17 like Neighboring gene saxophone Neighboring gene pummelig Neighboring gene cathepsin D Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
  2. Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association. Zhang W, et al. Curr Biol, 2021 Mar 8. PMID 33417882
  3. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
  4. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
  5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-glycine ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin tyrosine ligase-like 12
Names
CG1550-PA
TTLL12-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7810068..7812028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136481.3 → NP_610325.1  tubulin tyrosine ligase-like 12 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVG6
    Related
    FBpp0087973
    Conserved Domains (1) summary
    cl17255
    Location:328 → 613
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVG6 Q7JVG6

Gene LinkOut

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