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Dgk Diacyl glycerol kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35738, updated on 9-Dec-2024

Summary

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Official Symbol
Dgkprovided by FlyBase
Official Full Name
Diacyl glycerol kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0085390
Locus tag
Dmel_CG34361
See related
AllianceGenome:FB:FBgn0085390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12820; CG1535; CG18654; CG34361; DAGK; dDGK; dgk; DGK; DGKb; Dmel\CG34361
Old locus tag
CG12820; CG18654; Dmel_CG12820; Dmel_CG18654
Summary
Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelial tube; ganglia; indirect flight muscle cell; larval midline neurons; and sensory nervous system primordium. Used to study glucose metabolism disease. Orthologous to several human genes including DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Dgk in Genome Data Viewer
Location:
43E18-43F1; 2-57 cM
Exon count:
23
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7834812..7885982, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3722317..3773487, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Proteasome alpha1 subunit-related Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cullin 1 Neighboring gene Odorant receptor 43b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a Drosophila diacylglycerol kinase gene that is expressed in the nervous system and muscle. Masai I, et al. Proc Natl Acad Sci U S A, 1992 Jul 1. PMID 1321433, Free PMC Article
  2. A Drosophila gene encoding a protein with similarity to diacylglycerol kinase is expressed in specific neurons. Harden N, et al. Biochem J, 1993 Jan 15. PMID 8380995, Free PMC Article
  3. Partial purification and characterization of membrane-associated diacylglycerol kinase of Drosophila heads. Inoue H, et al. Biochim Biophys Acta, 1992 Jul 31. PMID 1322704
  4. DHR3: a Drosophila steroid receptor homolog. Koelle MR, et al. Proc Natl Acad Sci U S A, 1992 Jul 1. PMID 1631105, Free PMC Article
  5. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. McElwain MA, et al. PLoS One, 2011. PMID 22069480, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c7873962-7869244 mobile_element_type = transposon:Doc{}772

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diacyl glycerol kinase
Names
CG34361-PE
CG34361-PF
CG34361-PG
CG34361-PH
CG34361-PI
CG34361-PJ
CG34361-PK
Dgk-PE
Dgk-PF
Dgk-PG
Dgk-PH
Dgk-PI
Dgk-PJ
Dgk-PK
diacylglycerol kinase
NP_001097219.1
NP_001097220.1
NP_001260792.1
NP_001303337.1
NP_523654.2
NP_724619.2
NP_995775.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7834812..7885982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165568.3 → NP_724619.2  diacyl glycerol kinase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724619.2

    Status: REVIEWED

    Conserved Domains (7) summary
    smart00045
    Location:1003 → 1194
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:573 → 694
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:410 → 459
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:317 → 386
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:477 → 528
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:318 → 382
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:9 → 313
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. NM_001273863.1 → NP_001260792.1  diacyl glycerol kinase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEG4
    Conserved Domains (7) summary
    smart00045
    Location:873 → 1064
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:443 → 564
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:280 → 329
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:187 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:347 → 398
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:188 → 252
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:9 → 183
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. NM_001316408.1 → NP_001303337.1  diacyl glycerol kinase, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUN0
    Conserved Domains (7) summary
    smart00045
    Location:873 → 1064
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:443 → 564
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:280 → 329
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:187 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:347 → 398
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:188 → 252
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:9 → 183
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. NM_001103750.3 → NP_001097220.1  diacyl glycerol kinase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01583
    Conserved Domains (7) summary
    smart00045
    Location:881 → 1072
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:451 → 572
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:280 → 329
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:187 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:347 → 398
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:188 → 252
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:9 → 183
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. NM_078930.4 → NP_523654.2  diacyl glycerol kinase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523654.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01583
    Related
    FBpp0111491
    Conserved Domains (2) summary
    smart00045
    Location:564 → 755
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:134 → 255
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)

  6. NM_001103749.2 → NP_001097219.1  diacyl glycerol kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097219.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DY60, A8DY61, Q01583, Q53YF9, Q7KQR7, Q8MKP0, Q9V327
    Conserved Domains (7) summary
    smart00045
    Location:984 → 1175
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:554 → 675
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:383 → 432
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:290 → 359
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:450 → 501
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:291 → 355
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:9 → 286
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  7. NM_206053.2 → NP_995775.2  diacyl glycerol kinase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995775.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01583
    Conserved Domains (2) summary
    smart00045
    Location:520 → 711
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:90 → 211
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEG4 A0A0B4KEG4
A0A126GUN0 A0A126GUN0
Q01583.5 Q01583

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