Nup44A Nucleoporin at 44A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup44Aprovided by FlyBase
Official Full Name: Nucleoporin at 44Aprovided by FlyBase
Primary source: FLYBASE:FBgn0033247
Locus tag: Dmel_CG8722
See related: AllianceGenome:FB:FBgn0033247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8722; Dmel\CG8722; FBgn 33247; GATOR2; nup44A; Nup44A/Seh1; seh1; Seh1; SEH1
Summary: Predicted to enable structural molecule activity. Involved in several processes, including positive regulation of TORC1 signaling; positive regulation of cell size; and regulation of autophagy. Located in autolysosome and nuclear envelope. Part of Seh1-associated complex. Is expressed in adult head; nurse cell; oocyte; and ovariole. Orthologous to human SEH1L (SEH1 like nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44A2-44A2; 2-58 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7988462..7991283)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3875967..3878788)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.
Title: Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.
Like mio, seh1 has a crucial germline function during oogenesis. In both mio and seh1 mutant ovaries, a fraction of oocytes fail to maintain the meiotic cycle and develop as pseudo-nurse cells.
Title: The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GATOR2 complex	TAS Traceable Author Statement more info	PubMed
part_of Seh1-associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	ISS Inferred from Sequence or Structural Similarity more info
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: nucleoporin at 44A

Names: CG8722-PA; CG8722-PB; CG8722-PC; Nup44A-PA; Nup44A-PB; Nup44A-PC; nucleoporin 44A; nucleoporin-44A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7988462..7991283

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165582.2 → NP_724637.1 nucleoporin at 44A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724637.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K2X8

Related

FBpp0087936

Conserved Domains (2) summary

sd00039
Location:16 → 55

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_165583.2 → NP_724638.1 nucleoporin at 44A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724638.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K2X8

Related

FBpp0087937

Conserved Domains (2) summary

sd00039
Location:16 → 55

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_136499.3 → NP_610343.1 nucleoporin at 44A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610343.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K2X8

Related

FBpp0087938

Conserved Domains (2) summary

sd00039
Location:16 → 55

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...