U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dic3 Dicarboxylate carrier 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35763, updated on 9-Dec-2024

Summary

Official Symbol
Dic3provided by FlyBase
Official Full Name
Dicarboxylate carrier 3provided by FlyBase
Primary source
FLYBASE:FBgn0033248
Locus tag
Dmel_CG11196
See related
AllianceGenome:FB:FBgn0033248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11196; Dic3p; Dmel\CG11196
Summary
Enables phosphate transmembrane transporter activity; sulfate transmembrane transporter activity; and thiosulfate transmembrane transporter activity. Involved in phosphate ion transmembrane transport; sulfate transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dic3 in Genome Data Viewer
Location:
44A2-44A2; 2-58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7993798..7994968, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3881303..3882473, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Acetyl-CoA carboxylase Neighboring gene Nucleoporin at 44A Neighboring gene long non-coding RNA:CR44272 Neighboring gene Hairy/E(spl)-related with YRPW motif Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables malate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NOT involved_in malate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thiosulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dicarboxylate carrier 3
Names
CG11196-PA
CG11196-PB
Dic3-PA
Dic3-PB

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7993798..7994968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299250.1NP_001286179.1  dicarboxylate carrier 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEV4
    Conserved Domains (1) summary
    pfam00153
    Location:1591
    Mito_carr; Mitochondrial carrier protein
  2. NM_136500.3NP_610344.2  dicarboxylate carrier 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610344.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z787, Q8T406
    Related
    FBpp0087946
    Conserved Domains (2) summary
    PTZ00169
    Location:15275
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:200281
    Mito_carr; Mitochondrial carrier protein