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Odc2 Ornithine decarboxylase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35767, updated on 9-Dec-2024

Summary

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Official Symbol
Odc2provided by FlyBase
Official Full Name
Ornithine decarboxylase 2provided by FlyBase
Primary source
FLYBASE:FBgn0013308
Locus tag
Dmel_CG8719
See related
AllianceGenome:FB:FBgn0013308
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8719; Dmel\CG8719; dodc2
Summary
Predicted to enable ornithine decarboxylase activity. Predicted to be involved in putrescine biosynthetic process from ornithine. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1); AZIN2 (antizyme inhibitor 2); and ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Odc2 in Genome Data Viewer
Location:
44A2-44A2; 2-58 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8007246..8009062)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3894751..3896567)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ornithine decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene mir-4981 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the Drosophila ornithine decarboxylase locus: evidence for the presence of two transcribed ODC genes in the Drosophila genome. Rom E, et al. DNA Cell Biol, 1993 Jul-Aug. PMID 8329117
  2. Juvenile hormone stimulation of ornithine decarboxylase activity during vitellogenesis in Drosophila melanogaster. Birnbaum MJ, et al. J Comp Physiol B, 1990. PMID 2118148
  3. Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function. Coni S, et al. Elife, 2021 Sep 14. PMID 34517941, Free PMC Article
  4. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
  5. optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. Li Y, et al. Dev Biol, 2013 Sep 1. PMID 23792115, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine biosynthetic process from ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine decarboxylase 2
Names
CG8719-PA
Odc2-PA
NP_477053.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8007246..8009062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057705.4 → NP_477053.2  ornithine decarboxylase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477053.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40808, Q9V353
    Related
    FBpp0087940
    Conserved Domains (2) summary
    cd00622
    Location:30 → 390
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    COG0019
    Location:21 → 385
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40808.2 P40808

Gene LinkOut

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