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uno univalents only [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35778, updated on 9-Dec-2024

Summary

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Official Symbol
unoprovided by FlyBase
Official Full Name
univalents onlyprovided by FlyBase
Primary source
FLYBASE:FBgn0033258
Locus tag
Dmel_CG8712
See related
AllianceGenome:FB:FBgn0033258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8712; Dmel\CG8712
Summary
Enables chromatin binding activity. Involved in achiasmate meiosis I; homologous chromosome pairing at meiosis; and male meiosis I. Located in condensed chromosome; nucleolus; and nucleoplasm. Is expressed in embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See uno in Genome Data Viewer
Location:
44A4-44A4; 2-58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8096792..8098484, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3984297..3985989, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sugar transporter 2 Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene Transmembrane protein 63 Neighboring gene Cullin 4 Neighboring gene under-developed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Age-dependent diastolic heart failure in an in vivo Drosophila model. Klassen MP, et al. Elife, 2017 Mar 22. PMID 28328397, Free PMC Article
  2. Uncharted territories: Solving the mysteries of male meiosis in flies. Lee L, et al. PLoS Genet, 2024 Mar. PMID 38489251, Free PMC Article
  3. Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin. Kabakci Z, et al. PLoS Genet, 2022 Dec. PMID 36480577, Free PMC Article
  4. Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis. Kabakci Z, et al. PLoS Genet, 2022 Oct. PMID 36251690, Free PMC Article
  5. Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators. Vernizzi L, et al. PLoS Genet, 2021 Oct. PMID 34669718, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in achiasmate meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
univalents only
Names
CG8712-PA
CG8712-PB
uno-PA
uno-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8096792..8098484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165587.2 → NP_724644.1  univalents only, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724644.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQU5
    Related
    FBpp0087899

  2. NM_136506.3 → NP_610350.2  univalents only, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610350.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQU5
    Related
    FBpp0087898
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQU5 Q7JQU5

Gene LinkOut

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